Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 780938..781569 Replicon chromosome
Accession NZ_CP048537
Organism Agrobacterium tumefaciens strain SJ003

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FY140_RS14240 Protein ID WP_262535080.1
Coordinates 781171..781569 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FY140_RS14235 Protein ID WP_262535079.1
Coordinates 780938..781171 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY140_RS14210 (FY140_14110) 776379..777641 + 1263 WP_003520727.1 beta-ketoacyl-ACP synthase II -
FY140_RS14215 (FY140_14115) 777683..777958 + 276 WP_164865482.1 hypothetical protein -
FY140_RS14220 (FY140_14120) 777971..779191 + 1221 WP_020810689.1 endolytic transglycosylase MltG -
FY140_RS14225 (FY140_14125) 779259..780146 + 888 WP_262535078.1 YicC/YloC family endoribonuclease -
FY140_RS14230 (FY140_14130) 780152..780814 + 663 WP_080817281.1 guanylate kinase -
FY140_RS14235 (FY140_14135) 780938..781171 + 234 WP_262535079.1 antitoxin Antitoxin
FY140_RS14240 (FY140_14140) 781171..781569 + 399 WP_262535080.1 type II toxin-antitoxin system VapC family toxin Toxin
FY140_RS14245 (FY140_14145) 781601..782250 - 650 Protein_771 alpha/beta hydrolase -
FY140_RS14250 (FY140_14150) 782324..783154 - 831 WP_262535081.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
FY140_RS14255 (FY140_14155) 783154..784176 - 1023 WP_262535082.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
FY140_RS14260 (FY140_14160) 784203..785150 - 948 WP_080817277.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14869.08 Da        Isoelectric Point: 6.2251

>T149601 WP_262535080.1 NZ_CP048537:781171-781569 [Agrobacterium tumefaciens]
MLTYMLDTNICIYVMKTYPPDLRDKFNNLADELCISSITLGELYYGAEKSARRQENLSAIENFTARLEVLPFAEKGAAHY
GQIRAELARAGTPCGVHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

>T149601 NZ_CP064174:c4322288-4321878 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8682.82 Da        Isoelectric Point: 7.2042

>AT149601 WP_262535079.1 NZ_CP048537:780938-781171 [Agrobacterium tumefaciens]
MATSTVFTSNRSQAVRLPKAVAFPDDVHKVDILKVGLTRVIVPHGKRWDDLFLAGPRATEDFLSNREQPTSEERESF

Download         Length: 234 bp

>AT149601 NZ_CP064174:c4322535-4322269 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References