149600

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 592061..592686 Replicon chromosome
Accession NZ_CP048537
Organism Agrobacterium tumefaciens strain SJ003

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FY140_RS13230 Protein ID WP_137003111.1
Coordinates 592327..592686 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A420FBH4
Locus tag FY140_RS13225 Protein ID WP_059753836.1
Coordinates 592061..592327 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY140_RS13205 (FY140_13130) 587566..588390 + 825 WP_080817388.1 class D beta-lactamase -
FY140_RS13210 (FY140_13135) 588738..591320 + 2583 WP_262534971.1 heavy metal translocating P-type ATPase -
FY140_RS13215 (FY140_13140) 591317..591739 + 423 WP_127758198.1 Cu(I)-responsive transcriptional regulator -
FY140_RS13220 (FY140_13145) 591793..591993 + 201 WP_137452188.1 heavy-metal-associated domain-containing protein -
FY140_RS13225 (FY140_13150) 592061..592327 + 267 WP_059753836.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FY140_RS13230 (FY140_13155) 592327..592686 + 360 WP_137003111.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FY140_RS13235 (FY140_13160) 592756..593025 + 270 WP_262534972.1 type II toxin-antitoxin system ParD family antitoxin -
FY140_RS13240 (FY140_13165) 593015..593380 + 366 WP_262534973.1 type II toxin-antitoxin system RelE/ParE family toxin -
FY140_RS13245 (FY140_13170) 593377..593625 - 249 WP_080817381.1 hypothetical protein -
FY140_RS13250 (FY140_13175) 593817..595226 + 1410 WP_262535480.1 MFS transporter -
FY140_RS13255 595217..595339 - 123 WP_262534974.1 hypothetical protein -
FY140_RS13260 (FY140_13180) 595460..597178 - 1719 WP_137003117.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin

SpoVT-AbrB domain

(14-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12856.00 Da        Isoelectric Point: 8.2744

>T149600 WP_137003111.1 NZ_CP048537:592327-592686 [Agrobacterium tumefaciens]
MVRSQVPKRGDVYLVDLNPVIGSEIRDEHRCIVITPREINAVGLCLVVPVTTGGVFTRRAGLAVNISGPRTTGVALCNQV
RSMDIVARVAQKKAKYIETLDDATIDEIAGRVISMIDPA

Download         Length: 360 bp

>T149600 NZ_CP064174:c3315315-3315213 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9392.84 Da        Isoelectric Point: 4.5983

>AT149600 WP_059753836.1 NZ_CP048537:592061-592327 [Agrobacterium tumefaciens]
VTVTTRIRRQGGAAVMTIPPALLKMLGLEIGEQLTLEVDNGALVASPVRQEKKRFTLAELLEGADEVAALNASAREWDEA
PPVGKEAL

Download         Length: 267 bp

>AT149600 NZ_CP064174:3315206-3315351 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A420FBH4

References