Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 501597..502191 Replicon chromosome
Accession NZ_CP048537
Organism Agrobacterium tumefaciens strain SJ003

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FY140_RS12730 Protein ID WP_137003032.1
Coordinates 501877..502191 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FY140_RS12725 Protein ID WP_080833761.1
Coordinates 501597..501896 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY140_RS12700 (FY140_12625) 496760..497758 + 999 WP_262534924.1 asparaginase -
FY140_RS12705 (FY140_12630) 497893..498513 + 621 WP_080817456.1 glutathione S-transferase family protein -
FY140_RS12710 (FY140_12635) 498664..499323 - 660 WP_137452244.1 glutathione S-transferase family protein -
FY140_RS12715 (FY140_12640) 499406..499921 - 516 WP_003522221.1 MarR family transcriptional regulator -
FY140_RS12720 (FY140_12645) 500064..501560 + 1497 WP_262534925.1 MDR family MFS transporter -
FY140_RS12725 (FY140_12650) 501597..501896 - 300 WP_080833761.1 putative addiction module antidote protein Antitoxin
FY140_RS12730 (FY140_12655) 501877..502191 - 315 WP_137003032.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY140_RS12735 (FY140_12660) 502429..503439 + 1011 WP_262535552.1 ligase-associated DNA damage response exonuclease -
FY140_RS12740 (FY140_12665) 503441..505066 + 1626 WP_262534926.1 cisplatin damage response ATP-dependent DNA ligase -
FY140_RS12745 (FY140_12670) 505237..506202 + 966 WP_262534927.1 alpha/beta fold hydrolase -
FY140_RS12750 (FY140_12675) 506289..507071 - 783 WP_262534928.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11659.36 Da        Isoelectric Point: 10.3355

>T149599 WP_137003032.1 NZ_CP048537:c502191-501877 [Agrobacterium tumefaciens]
MNSFEKSAEFDEWLKALKDRAGKVRILHRLTAAEHGNFGDCEPVGGGVSEMRIHFGPGYRVYFTRVGKRIYFLLIGGDKS
SQKRDIKRAIGMAQTIGRDGRDGI

Download         Length: 315 bp

>T149599 NZ_CP064174:2577274-2578596 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10712.18 Da        Isoelectric Point: 4.6263

>AT149599 WP_080833761.1 NZ_CP048537:c501896-501597 [Agrobacterium tumefaciens]
MAVTEFSQFDVSDYLDSDEAMIEYLAVAMEDENPDVFIAALGAVARARGMSHVADASGLGRESLYKALKPGSKLRYETVQ
KVLHALGFRLAVEKSLSAA

Download         Length: 300 bp

>AT149599 NZ_CP064174:2577008-2577274 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References