Detailed information of TA system TA149593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 496836..497380
• Replicon: chromosome
• Accession: NZ_CP048532
• Organism: Agrobacterium tumefaciens strain Sta002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FY141_RS02505
• Protein ID: WP_173992172.1
• Coordinates: 497090..497380 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A822V4A8
• Locus tag: FY141_RS02500
• Protein ID: WP_003509084.1
• Coordinates: 496836..497087 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY141_RS02480 (FY141_02475)	492597..493277	+	681	WP_003509096.1	GntR family transcriptional regulator	-
FY141_RS02485 (FY141_02480)	493323..493799	+	477	WP_099085593.1	DUF1284 domain-containing protein	-
FY141_RS02490 (FY141_02485)	493975..495075	-	1101	WP_099085592.1	hypothetical protein	-
FY141_RS02495 (FY141_02490)	495312..496457	+	1146	WP_087743499.1	site-specific DNA-methyltransferase	-
FY141_RS02500 (FY141_02495)	496836..497087	+	252	WP_003509084.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FY141_RS02505 (FY141_02500)	497090..497380	+	291	WP_173992172.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY141_RS02510 (FY141_02505)	497422..498033	-	612	WP_087743505.1	HAD family phosphatase	-
FY141_RS02515 (FY141_02510)	498030..499142	-	1113	WP_099085591.1	A/G-specific adenine glycosylase	-
FY141_RS02520 (FY141_02515)	499270..499734	+	465	WP_020812858.1	hypothetical protein	-
FY141_RS02525 (FY141_02520)	499762..500283	+	522	WP_003509079.1	DUF721 domain-containing protein	-
FY141_RS02530 (FY141_02525)	500412..501092	+	681	WP_003509078.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (12-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11225.88 Da
• Isoelectric Point: 6.2182

>T149593 WP_173992172.1 NZ_CP048532:497090-497380 [Agrobacterium tumefaciens]
VGFRLSLLAEEDVIRIAEEGIAIFGLAQAQKYHRELYEIFELISLNPRMARERHELLPPLRIHRFRTHLVVYGVGADDDV
LIVRVRHAHEDWVNES

Nucleotide

• Length: 291 bp

>T149593 NZ_CP064170:1605411-1606727 [Vibrio crassostreae]
ATGCAACAACTTAATGCCTATATGAATGGTGAGTTGGTCGGTACTCTAACAAAGCAAAACAATGGCTCTCATGAATTTAA
ATATAATGAGTCTTGGCTAAGTAGCGACAAATCTCGCCCATTGTCTTTATCCCTTAAACTACAAATACCTACGATAACTT
CTGATGCCGTTATCAACTACTTTGACAACCTGCTACCAGACAATATTGCTATACGTAATAGGATTGTTGCACGCTATCAA
ACGGCTTCAAATCAACCTTTTGATCTTCTAAAAGAAATTGGCAAAGACAGCGTTGGTGCCATTGCTCTGCTCCCTCCAAG
TCAACCCTATATCGAGAACAAACTGTCATACGAACTTCTTGATGAATCTCGGCTTGAAAAAATCTTAGCAGCCCATCATT
CCGATATTCCATTAGGTATGATTAAGGAAGAAGATGATTTCCGAATATCGGTTGCTGGCGCTCAAGAAAAAACAGCATTA
CTAAGGTTGAATGGAGATTGGTGTTTGCCTAAAGGGAATACACCTACAAGCCATATCATTAAGCTACCTATTGGTGAGAT
TAAGCAGCCCACCTCTATTCTAGATCTGACTGAAAGTGTCGAGAATGAGTTCATATGTATTGAGTTAGCTAGAGAGTTGG
GGTTTGATGTTCCGACAGTCGAGATCATCACAACCCATAATTATAAAGCCATTGCTGTTGAGCGTTTTGATAGACGTTGG
ATTAAGGATCGTACACACCTACTGCGCCTTCCTCAGGAAGATATCTGTCAAGCCAAAGGAATCCCTTCATCGATAAAATA
CGAAAGTGATGGAGGCCCCGGAATCGCCGATATCATGAAGCTACTTGAAGGCTCATCAAATGCACTGGAAGACAGATATA
ACTTCATGAAGTTTCAAGTTTTCCAATGGGCTATAGGCGCTATTGATGGGCATGCAAAGAACTATTCAATATTTATTGAA
AAGCAAGGTAGTTATCGCTTAACACCATTTTATGACATTTTATCTGCTTACCCTATCACCGAAAAAAAAGGACTAAACAT
CAGAAAGTTAAAGTTAGCAATGGGGTTAAAAGCAAGCCGTGGTAAGAAATACCAGATAAGCAAGATCTACTCCCGCCACT
TTCTTGATACAGCCCATTCAGTTGGCTTTAATTCTGATAGCATGCAAAGCATATTGGATGACATGCAAACTGAATTACCC
AAAGCAATTGAGCGCCTCGCCGCACGCTTACCTGAAGGTTTCCCAAAACACATAACCGAAGCTATCTTTGATAACTCTAT
TGCCATGCTTAACAAATTGAATTTGGGCAAGAACTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9339.55 Da
• Isoelectric Point: 9.7317

>AT149593 WP_003509084.1 NZ_CP048532:496836-497087 [Agrobacterium tumefaciens]
MATMNISLPAPMKEWVEAQSRTGRYSNASDYVRDLIRKDQERGEKIAAMQHFVDEGLQSGAGHRSQQALFAEAEARSMKR
KIG

Nucleotide

• Length: 252 bp

>AT149593 NZ_CP064170:1605163-1605411 [Vibrio crassostreae]
GTGATTTATAGCCCACAACAATTAGCTAATACTTTACTGCTAATACGCCAAAAGAATAGATGGACTCAGTCTGAGCTGGC
AAAAAAAGTAGGGATAAAACAAGCAACCATTTCGAACTTTGAAAATAGACCAGAAAAGGCCACTATTTCAACAATGTTCA
AGCTCATACAAGCATTAGATCTGACCCTTAAAATAGAACCCAAAGATGTAAAAAATAGTCAAAGCACTGTTGGTGAGGAA
GATTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A822V4A8