Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 460546..461090 Replicon chromosome
Accession NZ_CP048528
Organism Agrobacterium tumefaciens strain Sta003

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FY142_RS02235 Protein ID WP_173992172.1
Coordinates 460800..461090 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A822V4A8
Locus tag FY142_RS02230 Protein ID WP_003509084.1
Coordinates 460546..460797 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY142_RS02210 (FY142_02205) 456307..456987 + 681 WP_003509096.1 GntR family transcriptional regulator -
FY142_RS02215 (FY142_02210) 457033..457509 + 477 WP_099085593.1 DUF1284 domain-containing protein -
FY142_RS02220 (FY142_02215) 457685..458785 - 1101 WP_099085592.1 hypothetical protein -
FY142_RS02225 (FY142_02220) 459022..460167 + 1146 WP_087743499.1 site-specific DNA-methyltransferase -
FY142_RS02230 (FY142_02225) 460546..460797 + 252 WP_003509084.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FY142_RS02235 (FY142_02230) 460800..461090 + 291 WP_173992172.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY142_RS02240 (FY142_02235) 461132..461743 - 612 WP_087743505.1 HAD family phosphatase -
FY142_RS02245 (FY142_02240) 461740..462852 - 1113 WP_099085591.1 A/G-specific adenine glycosylase -
FY142_RS02250 (FY142_02245) 462980..463444 + 465 WP_020812858.1 hypothetical protein -
FY142_RS02255 (FY142_02250) 463472..463993 + 522 WP_003509079.1 DUF721 domain-containing protein -
FY142_RS02260 (FY142_02255) 464122..464802 + 681 WP_003509078.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(12-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11225.88 Da        Isoelectric Point: 6.2182

>T149591 WP_173992172.1 NZ_CP048528:460800-461090 [Agrobacterium tumefaciens]
VGFRLSLLAEEDVIRIAEEGIAIFGLAQAQKYHRELYEIFELISLNPRMARERHELLPPLRIHRFRTHLVVYGVGADDDV
LIVRVRHAHEDWVNES

Download         Length: 291 bp

>T149591 NZ_CP064169:c55054-54896 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9339.55 Da        Isoelectric Point: 9.7317

>AT149591 WP_003509084.1 NZ_CP048528:460546-460797 [Agrobacterium tumefaciens]
MATMNISLPAPMKEWVEAQSRTGRYSNASDYVRDLIRKDQERGEKIAAMQHFVDEGLQSGAGHRSQQALFAEAEARSMKR
KIG

Download         Length: 252 bp

>AT149591 NZ_CP064169:c55317-55119 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A822V4A8

References