Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 480182..480762 Replicon plasmid pAt
Accession NZ_CP048520
Organism Agrobacterium tumefaciens strain Sta005

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FY144_RS26125 Protein ID WP_121593637.1
Coordinates 480379..480762 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FY144_RS26120 Protein ID WP_080868762.1
Coordinates 480182..480382 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY144_RS26105 (FY144_25915) 476066..476644 + 579 WP_121593634.1 helix-turn-helix domain-containing protein -
FY144_RS26110 (FY144_25920) 476743..478857 - 2115 WP_233283060.1 EAL domain-containing protein -
FY144_RS26115 (FY144_25925) 479664..479990 - 327 WP_121593636.1 transposase -
FY144_RS26120 (FY144_25930) 480182..480382 + 201 WP_080868762.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FY144_RS26125 (FY144_25935) 480379..480762 + 384 WP_121593637.1 type II toxin-antitoxin system VapC family toxin Toxin
FY144_RS26130 (FY144_25940) 481105..481301 - 197 Protein_507 aldo/keto reductase -
FY144_RS26135 481460..481768 - 309 Protein_508 gfo/Idh/MocA family oxidoreductase -
FY144_RS26140 (FY144_25945) 481753..482007 + 255 Protein_509 helix-turn-helix domain-containing protein -
FY144_RS26145 (FY144_25955) 482556..483407 - 852 WP_121593638.1 2-hydroxy-3-oxopropionate reductase -
FY144_RS26150 (FY144_25960) 483411..484196 - 786 WP_060724635.1 hydroxypyruvate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..520191 520191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14114.32 Da        Isoelectric Point: 7.0612

>T149590 WP_121593637.1 NZ_CP048520:480379-480762 [Agrobacterium tumefaciens]
VILVDTSIWIDHFRYGDSELRKIIEGDRLLCHPAIIGELALGRLRDRDAVMAYFAAQREAFVATHAEVMTMIDRHSIFSM
GIGYTDAHLLASTLLDGRSSLWTRDKRLTAAAQKAGAVLHAPMIPPN

Download         Length: 384 bp

>T149590 NZ_CP064169:c31827-31552 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7210.28 Da        Isoelectric Point: 11.3760

>AT149590 WP_080868762.1 NZ_CP048520:480182-480382 [Agrobacterium tumefaciens]
MRSTINLDDNLMERARSLTGTKETAALVRQALETLVRVESGKRLLALGGSMPDAQAAPRRRSEATK

Download         Length: 201 bp

>AT149590 NZ_CP064169:c32111-31827 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References