Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 583014..583621 Replicon chromosome
Accession NZ_CP048518
Organism Agrobacterium tumefaciens strain Sta005

Toxin (Protein)


Gene name relE Uniprot ID A0A822V529
Locus tag FY144_RS02885 Protein ID WP_060723952.1
Coordinates 583014..583349 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A822V573
Locus tag FY144_RS02890 Protein ID WP_020811442.1
Coordinates 583346..583621 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY144_RS02870 (FY144_02865) 579067..581259 - 2193 WP_121592189.1 transglycosylase domain-containing protein -
FY144_RS02875 (FY144_02870) 581514..581993 + 480 WP_060723951.1 YcgN family cysteine cluster protein -
FY144_RS02880 (FY144_02875) 582162..582986 + 825 WP_003509224.1 class D beta-lactamase -
FY144_RS02885 (FY144_02880) 583014..583349 - 336 WP_060723952.1 type II toxin-antitoxin system YafQ family toxin Toxin
FY144_RS02890 (FY144_02885) 583346..583621 - 276 WP_020811442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FY144_RS02895 583620..583784 + 165 WP_153463487.1 hypothetical protein -
FY144_RS02900 (FY144_02890) 583834..586413 + 2580 WP_065694911.1 heavy metal translocating P-type ATPase -
FY144_RS02905 (FY144_02895) 586410..586832 + 423 WP_003509219.1 Cu(I)-responsive transcriptional regulator -
FY144_RS02910 (FY144_02900) 586885..587085 + 201 WP_060723954.1 heavy-metal-associated domain-containing protein -
FY144_RS02915 (FY144_02905) 587162..587431 + 270 WP_003509217.1 type II toxin-antitoxin system ParD family antitoxin -
FY144_RS02920 (FY144_02910) 587421..587786 + 366 WP_060723955.1 hypothetical protein -
FY144_RS02925 (FY144_02915) 587783..588031 - 249 WP_060723956.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(24-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12983.80 Da        Isoelectric Point: 9.0022

>T149586 WP_060723952.1 NZ_CP048518:c583349-583014 [Agrobacterium tumefaciens]
VTDKKGHGKEAASKRTVLPRSSDFTRQFIKDWQRLNNSGRYDMVKLKEIMLLHIANEAPLPAQFRDHELTGEWHDHRECH
VGGDFLLIYKLDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

>T149586 NZ_CP064167:4031450-4031857 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9930.42 Da        Isoelectric Point: 8.6855

>AT149586 WP_020811442.1 NZ_CP048518:c583621-583346 [Agrobacterium tumefaciens]
MTANAYVRARIDQALKDDATAVLDSLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAARRNRFGTAQ
ALFDALDGNKR

Download         Length: 276 bp

>AT149586 NZ_CP064167:4031203-4031469 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822V529

Antitoxin

Source ID Structure
AlphaFold DB A0A822V573

References