Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 599452..600059 Replicon chromosome
Accession NZ_CP048497
Organism Agrobacterium tumefaciens strain Teh002

Toxin (Protein)


Gene name relE Uniprot ID A0A1S7Q870
Locus tag FY148_RS02945 Protein ID WP_031234113.1
Coordinates 599452..599787 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A822V573
Locus tag FY148_RS02950 Protein ID WP_020811442.1
Coordinates 599784..600059 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY148_RS02925 (FY148_02940) 594494..595393 + 900 WP_262513326.1 LysR family transcriptional regulator ArgP -
FY148_RS02930 (FY148_02945) 595505..597697 - 2193 WP_003509229.1 transglycosylase domain-containing protein -
FY148_RS02935 (FY148_02950) 597952..598431 + 480 WP_003509227.1 YcgN family cysteine cluster protein -
FY148_RS02940 (FY148_02955) 598600..599424 + 825 WP_003509224.1 class D beta-lactamase -
FY148_RS02945 (FY148_02960) 599452..599787 - 336 WP_031234113.1 type II toxin-antitoxin system YafQ family toxin Toxin
FY148_RS02950 (FY148_02965) 599784..600059 - 276 WP_020811442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FY148_RS02955 (FY148_02970) 600058..600222 + 165 WP_262513327.1 hypothetical protein -
FY148_RS02960 (FY148_02975) 600272..602851 + 2580 WP_262513328.1 heavy metal translocating P-type ATPase -
FY148_RS02965 (FY148_02980) 602848..603270 + 423 WP_060726101.1 Cu(I)-responsive transcriptional regulator -
FY148_RS02970 (FY148_02985) 603323..603523 + 201 WP_112277689.1 heavy-metal-associated domain-containing protein -
FY148_RS02975 (FY148_02990) 603600..603869 + 270 WP_003509217.1 type II toxin-antitoxin system ParD family antitoxin -
FY148_RS02980 (FY148_02995) 603859..604224 + 366 WP_087743607.1 KluB -
FY148_RS02985 (FY148_03000) 604221..604469 - 249 WP_003509215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(24-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12959.82 Da        Isoelectric Point: 8.9995

>T149577 WP_031234113.1 NZ_CP048497:c599787-599452 [Agrobacterium tumefaciens]
VTDKKGHGKEAASKRTVLPRSSDFTRQFIKDWQRLNNSGRYDMVKLKEIMLLLIANEAPLPAQFRDHELTGEWHDHRECH
VGGDFLLIYKLDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

>T149577 NZ_CP064167:c2514421-2514071 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9930.42 Da        Isoelectric Point: 8.6855

>AT149577 WP_020811442.1 NZ_CP048497:c600059-599784 [Agrobacterium tumefaciens]
MTANAYVRARIDQALKDDATAVLDSLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAARRNRFGTAQ
ALFDALDGNKR

Download         Length: 276 bp

>AT149577 NZ_CP064167:c2514666-2514415 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7Q870

Antitoxin

Source ID Structure
AlphaFold DB A0A822V573

References