Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 617116..617723 Replicon chromosome
Accession NZ_CP048481
Organism Agrobacterium tumefaciens strain Tul004

Toxin (Protein)


Gene name relE Uniprot ID A0A1S7Q870
Locus tag FY153_RS03145 Protein ID WP_031234113.1
Coordinates 617116..617451 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A822V573
Locus tag FY153_RS03150 Protein ID WP_020811442.1
Coordinates 617448..617723 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY153_RS03125 (FY153_03130) 612158..613057 + 900 WP_262513326.1 LysR family transcriptional regulator ArgP -
FY153_RS03130 (FY153_03135) 613169..615361 - 2193 WP_003509229.1 transglycosylase domain-containing protein -
FY153_RS03135 (FY153_03140) 615616..616095 + 480 WP_003509227.1 YcgN family cysteine cluster protein -
FY153_RS03140 (FY153_03145) 616264..617088 + 825 WP_003509224.1 class D beta-lactamase -
FY153_RS03145 (FY153_03150) 617116..617451 - 336 WP_031234113.1 type II toxin-antitoxin system YafQ family toxin Toxin
FY153_RS03150 (FY153_03155) 617448..617723 - 276 WP_020811442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FY153_RS03155 (FY153_03160) 617722..617886 + 165 WP_262513327.1 hypothetical protein -
FY153_RS03160 (FY153_03165) 617936..620515 + 2580 WP_262513328.1 heavy metal translocating P-type ATPase -
FY153_RS03165 (FY153_03170) 620512..620934 + 423 WP_060726101.1 Cu(I)-responsive transcriptional regulator -
FY153_RS03170 (FY153_03175) 620987..621187 + 201 WP_112277689.1 heavy-metal-associated domain-containing protein -
FY153_RS03175 (FY153_03180) 621264..621533 + 270 WP_003509217.1 type II toxin-antitoxin system ParD family antitoxin -
FY153_RS03180 (FY153_03185) 621523..621888 + 366 WP_087743607.1 KluB -
FY153_RS03185 (FY153_03190) 621885..622133 - 249 WP_003509215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(24-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12959.82 Da        Isoelectric Point: 8.9995

>T149573 WP_031234113.1 NZ_CP048481:c617451-617116 [Agrobacterium tumefaciens]
VTDKKGHGKEAASKRTVLPRSSDFTRQFIKDWQRLNNSGRYDMVKLKEIMLLLIANEAPLPAQFRDHELTGEWHDHRECH
VGGDFLLIYKLDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

>T149573 NZ_CP064167:c2029948-2029550 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9930.42 Da        Isoelectric Point: 8.6855

>AT149573 WP_020811442.1 NZ_CP048481:c617723-617448 [Agrobacterium tumefaciens]
MTANAYVRARIDQALKDDATAVLDSLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAARRNRFGTAQ
ALFDALDGNKR

Download         Length: 276 bp

>AT149573 NZ_CP064167:c2030244-2029951 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7Q870

Antitoxin

Source ID Structure
AlphaFold DB A0A822V573

References