Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 902064..903587 Replicon chromosome
Accession NZ_CP048478
Organism Agrobacterium tumefaciens strain Yol001

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag FY154_RS18360 Protein ID WP_262514616.1
Coordinates 902343..903587 (+) Length 415 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag FY154_RS18355 Protein ID WP_262514615.1
Coordinates 902064..902330 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY154_RS18335 (FY154_18230) 897223..898164 + 942 WP_080867003.1 sugar phosphate isomerase/epimerase -
FY154_RS18340 (FY154_18235) 898220..899149 + 930 WP_112489079.1 TIM barrel protein -
FY154_RS18345 (FY154_18240) 899319..901034 + 1716 WP_262514613.1 AIPR family protein -
FY154_RS18350 (FY154_18245) 901324..901698 - 375 WP_262514614.1 hypothetical protein -
FY154_RS18355 (FY154_18250) 902064..902330 + 267 WP_262514615.1 helix-turn-helix transcriptional regulator Antitoxin
FY154_RS18360 (FY154_18255) 902343..903587 + 1245 WP_262514616.1 type II toxin-antitoxin system HipA family toxin Toxin
FY154_RS18365 (FY154_18260) 904070..905179 + 1110 WP_262514617.1 hypothetical protein -
FY154_RS18370 (FY154_18265) 905706..906614 + 909 WP_262514618.1 hypothetical protein -
FY154_RS18375 (FY154_18270) 906698..907117 + 420 WP_262514619.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(16-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 415 a.a.        Molecular weight: 45818.30 Da        Isoelectric Point: 6.6937

>T149571 WP_262514616.1 NZ_CP048478:902343-903587 [Agrobacterium tumefaciens]
VTTIFYESLPVANLIDRDGISLAYEPSWEQRASAFPISLTMPLRSGTYGAEQVMPWLANLLPETHLSEIGQQLKVSPQDI
VGLLTRLGRDTAGAFSIGEPRRDGNNFRVVPDEAALERILNELPERPFLVGEQGVSMSLAGVQDKLPVYLAEDGKIAIPV
DGTPSTHILKPDIRRLTSSVQNEAFCMTLARLCELETAEVTTGRAGSRDYLLVKRYDRIADAEGTIRRVHQEDFCQLLGL
FPSEKYERTGLGQRGGASLVHMFEALARYVSPAERLKLLDAVMFNILICNSDSHAKNYSVLVGAAGTAKLAPLYDLMCAA
VYKQVDQSLPQQIATKSNANELHGNDWRQFASAVGLSPAVVTKRIRELSDRVASKLEEALGETERHPSFHRDFGENLRFL
IRKRCQRIGRQAVG

Download         Length: 1245 bp

>T149571 NZ_CP064167:1318365-1318751 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9620.86 Da        Isoelectric Point: 5.8324

>AT149571 WP_262514615.1 NZ_CP048478:902064-902330 [Agrobacterium tumefaciens]
MIRSAAEFGALVREHRKKQGWTQTQLAERCGTGERFIVDLENGKPSCQLEKSLIAARTVGIDLGDLKTASPPATSEADDD
LGYLPRFS

Download         Length: 267 bp

>AT149571 NZ_CP064167:1318741-1319070 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References