Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 586793..587400 Replicon chromosome
Accession NZ_CP048477
Organism Agrobacterium tumefaciens strain Yol001

Toxin (Protein)


Gene name relE Uniprot ID A0A1S7Q870
Locus tag FY154_RS02915 Protein ID WP_031234113.1
Coordinates 586793..587128 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A822V573
Locus tag FY154_RS02920 Protein ID WP_020811442.1
Coordinates 587125..587400 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY154_RS02900 (FY154_02900) 582846..585038 - 2193 WP_003509229.1 transglycosylase domain-containing protein -
FY154_RS02905 (FY154_02905) 585293..585772 + 480 WP_003509227.1 YcgN family cysteine cluster protein -
FY154_RS02910 (FY154_02910) 585941..586765 + 825 WP_003509224.1 class D beta-lactamase -
FY154_RS02915 (FY154_02915) 586793..587128 - 336 WP_031234113.1 type II toxin-antitoxin system YafQ family toxin Toxin
FY154_RS02920 (FY154_02920) 587125..587400 - 276 WP_020811442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FY154_RS02925 (FY154_02925) 587613..590192 + 2580 WP_262514292.1 heavy metal translocating P-type ATPase -
FY154_RS02930 (FY154_02930) 590189..590611 + 423 WP_003509219.1 Cu(I)-responsive transcriptional regulator -
FY154_RS02935 (FY154_02935) 590664..590864 + 201 WP_003509218.1 heavy-metal-associated domain-containing protein -
FY154_RS02940 (FY154_02940) 590941..591210 + 270 WP_003509217.1 type II toxin-antitoxin system ParD family antitoxin -
FY154_RS02945 (FY154_02945) 591200..591565 + 366 WP_112277691.1 type II toxin-antitoxin system RelE/ParE family toxin -
FY154_RS02950 (FY154_02950) 591562..591810 - 249 WP_003509215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(24-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12959.82 Da        Isoelectric Point: 8.9995

>T149569 WP_031234113.1 NZ_CP048477:c587128-586793 [Agrobacterium tumefaciens]
VTDKKGHGKEAASKRTVLPRSSDFTRQFIKDWQRLNNSGRYDMVKLKEIMLLLIANEAPLPAQFRDHELTGEWHDHRECH
VGGDFLLIYKLDEKQNLLIFTRAGTHAELFR

Download         Length: 336 bp

>T149569 NZ_CP064167:c965968-965865 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9930.42 Da        Isoelectric Point: 8.6855

>AT149569 WP_020811442.1 NZ_CP048477:c587400-587125 [Agrobacterium tumefaciens]
MTANAYVRARIDQALKDDATAVLDSLGLTVSDVMRMMLTRIAREKALPIELTQPNAETLAAIEEARAIAAARRNRFGTAQ
ALFDALDGNKR

Download         Length: 276 bp

>AT149569 NZ_CP064167:965827-966098 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7Q870

Antitoxin

Source ID Structure
AlphaFold DB A0A822V573

References