Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 322674..323265 Replicon plasmid pAt
Accession NZ_CP048471
Organism Agrobacterium tumefaciens strain Yub001

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FY156_RS29060 Protein ID WP_262528675.1
Coordinates 322674..322970 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FY156_RS29065 Protein ID WP_262528677.1
Coordinates 322972..323265 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY156_RS29030 (FY156_28825) 318480..318737 + 258 WP_262528668.1 type II toxin-antitoxin system VapB family antitoxin -
FY156_RS29035 (FY156_28830) 318734..319138 + 405 WP_262528670.1 type II toxin-antitoxin system VapC family toxin -
FY156_RS29040 (FY156_28835) 319135..320277 + 1143 WP_262528671.1 tyrosine-type recombinase/integrase -
FY156_RS29045 (FY156_28840) 320460..321503 + 1044 WP_262528673.1 GSU2403 family nucleotidyltransferase fold protein -
FY156_RS29050 (FY156_28845) 321743..322030 + 288 Protein_327 Tn3 family transposase -
FY156_RS29055 (FY156_28850) 322061..322642 + 582 WP_262528674.1 hypothetical protein -
FY156_RS29060 (FY156_28855) 322674..322970 + 297 WP_262528675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY156_RS29065 (FY156_28860) 322972..323265 + 294 WP_262528677.1 putative addiction module antidote protein Antitoxin
FY156_RS29070 (FY156_28865) 324056..324376 + 321 WP_262528678.1 DUF736 domain-containing protein -
FY156_RS29075 (FY156_28870) 324457..324699 - 243 WP_262528679.1 WGR domain-containing protein -
FY156_RS29080 (FY156_28875) 325146..326000 + 855 WP_262528680.1 DUF932 domain-containing protein -
FY156_RS29085 (FY156_28880) 326000..326308 + 309 WP_262528681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..401476 401476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10975.72 Da        Isoelectric Point: 10.3887

>T149560 WP_262528675.1 NZ_CP048471:322674-322970 [Agrobacterium tumefaciens]
MIELKQTSTFAKWEARLRDRRARTMIAARLMRLAAGLPGDVEPVGEGVSELRIHYGPGYRVYFQQRGDVLIVLLCGGNKG
SQSNDIAKAKKLAKEWSE

Download         Length: 297 bp

>T149560 NZ_CP064129:4332454-4332738 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10324.75 Da        Isoelectric Point: 5.8373

>AT149560 WP_262528677.1 NZ_CP048471:322972-323265 [Agrobacterium tumefaciens]
MTEKLSTYDPAAALVDDEEIAAFMADAFETGDAAYIAKALGVVARAKGMSEISRKTGLSREQLYRSFSERGNPTLKTTLA
VMRALGVDVTAKAHAPS

Download         Length: 294 bp

>AT149560 NZ_CP064129:4332222-4332464 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References