Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 183939..184519 Replicon plasmid pAt
Accession NZ_CP048471
Organism Agrobacterium tumefaciens strain Yub001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FY156_RS28415 Protein ID WP_262528991.1
Coordinates 184136..184519 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FY156_RS28410 Protein ID WP_262528861.1
Coordinates 183939..184139 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY156_RS28390 (FY156_28210) 179535..179960 + 426 WP_262528986.1 response regulator -
FY156_RS28395 (FY156_28215) 179991..182303 + 2313 WP_262528988.1 GAF domain-containing protein -
FY156_RS28400 (FY156_28220) 182306..182680 + 375 WP_262528990.1 response regulator -
FY156_RS28405 (FY156_28225) 182831..183784 + 954 Protein_198 LysR family transcriptional regulator -
FY156_RS28410 (FY156_28230) 183939..184139 + 201 WP_262528861.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FY156_RS28415 (FY156_28235) 184136..184519 + 384 WP_262528991.1 type II toxin-antitoxin system VapC family toxin Toxin
FY156_RS28420 184577..184824 - 248 Protein_201 type II toxin-antitoxin system RelE/ParE family toxin -
FY156_RS28425 (FY156_28240) 185580..186388 - 809 Protein_202 oxidoreductase -
FY156_RS28430 (FY156_28245) 186621..187209 - 589 Protein_203 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..401476 401476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13868.86 Da        Isoelectric Point: 6.2081

>T149558 WP_262528991.1 NZ_CP048471:184136-184519 [Agrobacterium tumefaciens]
VILVDSSIWIDHFRHGGSELTKIIGDDQLLCHPFVVGELALGSLRDRDAVLAFLAAQREAVVATHAEVMTVIDRYSVFSM
GIGYTDVHLLTSTLLDQRSSLWTRDNRLAAAAQKVGAALYPSANIPH

Download         Length: 384 bp

>T149558 NZ_CP064129:3847614-3847997 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7243.45 Da        Isoelectric Point: 10.7407

>AT149558 WP_262528861.1 NZ_CP048471:183939-184139 [Agrobacterium tumefaciens]
MRSTISLDDKLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPEAEVAPRRRSEVSM

Download         Length: 201 bp

>AT149558 NZ_CP064129:3847372-3847614 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References