Detailed information of TA system TA149553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 44004..44551
• Replicon: plasmid pAt
• Accession: NZ_CP048471
• Organism: Agrobacterium tumefaciens strain Yub001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FY156_RS27630
• Protein ID: WP_262528818.1
• Coordinates: 44258..44551 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FY156_RS27625
• Protein ID: WP_262528815.1
• Coordinates: 44004..44258 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY156_RS27595 (FY156_27435)	39020..39478	+	459	WP_262528807.1	type II toxin-antitoxin system VapC family toxin	-
FY156_RS27600 (FY156_27440)	39688..39984	+	297	WP_262528810.1	nucleotidyltransferase domain-containing protein	-
FY156_RS27605 (FY156_27445)	40458..41725	-	1268	Protein_38	hypothetical protein	-
FY156_RS27610 (FY156_27450)	41927..43033	+	1107	WP_262528811.1	Fic family protein	-
FY156_RS27615 (FY156_27455)	43178..43465	-	288	WP_262528813.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FY156_RS27620 (FY156_27460)	43469..43735	-	267	WP_262528814.1	type II toxin-antitoxin system ParD family antitoxin	-
FY156_RS27625 (FY156_27465)	44004..44258	+	255	WP_262528815.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FY156_RS27630 (FY156_27470)	44258..44551	+	294	WP_262528818.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FY156_RS27635 (FY156_27475)	44702..44956	+	255	WP_077548947.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FY156_RS27640 (FY156_27480)	44953..45375	+	423	WP_262528819.1	type II toxin-antitoxin system VapC family toxin	-
FY156_RS27645 (FY156_27485)	46079..47017	-	939	WP_262528820.1	LysR family transcriptional regulator	-
FY156_RS27650 (FY156_27490)	47173..48159	+	987	WP_262528821.1	tripartite tricarboxylate transporter substrate binding protein	-
FY156_RS27655 (FY156_27495)	48252..48698	+	447	WP_262528823.1	tripartite tricarboxylate transporter TctB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB / htpB	1..401476	401476

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (6-77)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11104.76 Da
• Isoelectric Point: 6.3282

>T149553 WP_262528818.1 NZ_CP048471:44258-44551 [Agrobacterium tumefaciens]
MPFNLSVQAEEDIVSIAEEGIRVFGALVAKRYHDELFALFELIAANPRMARERNEISPPVRIHPFKAHLIVYRTIENGSI
LVIRIRHGHEDWGGDPF

Nucleotide

• Length: 294 bp

>T149553 NZ_CP064129:c1942417-1942315 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9369.37 Da
• Isoelectric Point: 4.7881

>AT149553 WP_262528815.1 NZ_CP048471:44004-44258 [Agrobacterium tumefaciens]
MATMNVSLPDPMKDWVEAQAKTGRYSNASDYVRDLIRRDQARTDKIAEMQRFVDDGIESGVGNQSSDELFAAAKARAKIS
SDRD

Nucleotide

• Length: 255 bp

>AT149553 NZ_CP064129:1942308-1942453 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT