Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4368..4999 Replicon chromosome
Accession NZ_CP048470
Organism Agrobacterium tumefaciens strain Yub001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FY156_RS16635 Protein ID WP_262526286.1
Coordinates 4368..4769 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FY156_RS16640 Protein ID WP_262526287.1
Coordinates 4769..4999 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY156_RS16590 (FY156_16520) 1..569 + 569 WP_262526278.1 hypothetical protein -
FY156_RS16595 (FY156_16525) 599..943 + 345 WP_262526279.1 nucleotidyltransferase domain-containing protein -
FY156_RS16600 (FY156_16530) 1039..1329 + 291 WP_262526280.1 type II toxin-antitoxin system ParD family antitoxin -
FY156_RS16605 (FY156_16535) 1345..1644 + 300 WP_262528477.1 type II toxin-antitoxin system RelE/ParE family toxin -
FY156_RS16610 (FY156_16540) 1777..2127 + 351 WP_262526281.1 MbcA/ParS/Xre antitoxin family protein -
FY156_RS16615 (FY156_16545) 2131..2628 + 498 WP_262526282.1 RES domain-containing protein -
FY156_RS16620 (FY156_16550) 2640..3452 - 813 WP_262526283.1 DUF4242 domain-containing protein -
FY156_RS16625 3690..3824 + 135 WP_262526284.1 hypothetical protein -
FY156_RS16630 (FY156_16555) 3839..4114 + 276 WP_262526285.1 helix-turn-helix transcriptional regulator -
FY156_RS16635 (FY156_16560) 4368..4769 - 402 WP_262526286.1 tRNA(fMet)-specific endonuclease VapC Toxin
FY156_RS16640 (FY156_16565) 4769..4999 - 231 WP_262526287.1 antitoxin Antitoxin
FY156_RS16645 (FY156_16570) 5207..5692 + 486 WP_262526288.1 BA14K family protein -
FY156_RS16650 (FY156_16575) 5971..7035 + 1065 WP_262526289.1 class I SAM-dependent methyltransferase -
FY156_RS16655 7892..8101 + 210 WP_262526290.1 hypothetical protein -
FY156_RS16660 (FY156_16585) 9181..9419 + 239 Protein_14 hypothetical protein -
FY156_RS16665 (FY156_16590) 9659..9829 + 171 WP_262526291.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14994.23 Da        Isoelectric Point: 8.4922

>T149552 WP_262526286.1 NZ_CP048470:c4769-4368 [Agrobacterium tumefaciens]
MLKYMLDTNICIFTIKNKPQQVRDAFNLRSGQLCISSVSLMELIYGAEKSVSPKRNLDVVEGFASRLEVLPYDDIAASHT
AQLRAELVRNGTPIGPYDQLIAGHARSRGFIVVTNNRREFDRVPGLRVEDWTV

Download         Length: 402 bp

>T149552 NZ_CP064129:1191041-1192363 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACACTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8457.46 Da        Isoelectric Point: 4.3719

>AT149552 WP_262526287.1 NZ_CP048470:c4999-4769 [Agrobacterium tumefaciens]
MEQGAVFQSNRSQAIRLPKAVALPDDVKRVDIVAIGRTRIIAPAGEIWDSWFEGPEASADFMNDRDQPAAQEREAF

Download         Length: 231 bp

>AT149552 NZ_CP064129:1190775-1191041 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGTCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References