Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2013366..2014002 Replicon chromosome
Accession NZ_CP048469
Organism Agrobacterium tumefaciens strain Yub001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FY156_RS10365 Protein ID WP_023100950.1
Coordinates 2013592..2014002 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FY156_RS10360 Protein ID WP_041862774.1
Coordinates 2013366..2013599 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY156_RS10340 (FY156_10295) 2009727..2010107 + 381 Protein_2039 DNA cytosine methyltransferase -
FY156_RS10345 (FY156_10300) 2010325..2011809 + 1485 WP_262522844.1 IS21 family transposase -
FY156_RS10350 (FY156_10305) 2011806..2012648 + 843 WP_113178757.1 IS21-like element helper ATPase IstB -
FY156_RS10355 (FY156_10310) 2013021..2013269 + 249 WP_012248365.1 hypothetical protein -
FY156_RS10360 (FY156_10315) 2013366..2013599 + 234 WP_041862774.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FY156_RS10365 (FY156_10320) 2013592..2014002 + 411 WP_023100950.1 PIN domain-containing protein Toxin
FY156_RS10370 (FY156_10325) 2014065..2014442 + 378 WP_262522847.1 DUF3742 family protein -
FY156_RS10375 (FY156_10330) 2014451..2015968 - 1518 WP_262522848.1 conjugal transfer protein TraG N-terminal domain-containing protein -
FY156_RS10380 (FY156_10335) 2015984..2016334 - 351 WP_262522849.1 hypothetical protein -
FY156_RS10385 (FY156_10340) 2016331..2017737 - 1407 WP_262522850.1 integrating conjugative element protein -
FY156_RS10390 (FY156_10345) 2017739..2018683 - 945 WP_262522852.1 TIGR03756 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-118)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15254.48 Da        Isoelectric Point: 5.1444

>T149551 WP_023100950.1 NZ_CP048469:2013592-2014002 [Agrobacterium tumefaciens]
VAKFKHFLDSNVVLYLLSSDADKADNAEALLKASPVISVQVLNEVTNVCLRKLQMSWDEIAQFLELVRSFCRVVPLTETI
HDQARWVAEQHRLSFYDACIVAAAAAANCSTLYSEDMNHGQILEDSLTIRNPFVVK

Download         Length: 411 bp

>T149551 NZ_CP064128:3726757-3727182 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8620.89 Da        Isoelectric Point: 8.8316

>AT149551 WP_041862774.1 NZ_CP048469:2013366-2013599 [Agrobacterium tumefaciens]
MQVAKWGNSLAVRLPATLVEALELREGDDIEIIVDDPRTFAVRKKPGADALLERLRAFRGKLPADFRFSRDEANARG

Download         Length: 234 bp

>AT149551 NZ_CP064128:3726510-3726776 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References