Detailed information of TA system TA149539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1234060..1234594
• Replicon: chromosome
• Accession: NZ_CP048458
• Organism: Burkholderia multivorans strain P1Bm2011a

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G0D87_RS20835
• Protein ID: WP_155825023.1
• Coordinates: 1234060..1234359 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: J4RB90
• Locus tag: G0D87_RS20840
• Protein ID: WP_006413656.1
• Coordinates: 1234349..1234594 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D87_RS20820	1230409..1231716	+	1308	WP_039218025.1	shikimate transporter	-
G0D87_RS20825	1231751..1232479	-	729	WP_155825024.1	HNH endonuclease	-
G0D87_RS20830	1232650..1233951	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
G0D87_RS20835	1234060..1234359	-	300	WP_155825023.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D87_RS20840	1234349..1234594	-	246	WP_006413656.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G0D87_RS20845	1234734..1235504	+	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
G0D87_RS20850	1235535..1237835	-	2301	WP_155825022.1	ATP-dependent DNA helicase	-
G0D87_RS20855	1237832..1239535	-	1704	WP_206382439.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11542.04 Da
• Isoelectric Point: 7.3154

>T149539 WP_155825023.1 NZ_CP048458:c1234359-1234060 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVAFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T149539 NZ_CP064126:3370610-3370813 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8632.71 Da
• Isoelectric Point: 6.4604

>AT149539 WP_006413656.1 NZ_CP048458:c1234594-1234349 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT149539 NZ_CP064126:3370193-3370561 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3KUX0