Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 805135..805826 Replicon chromosome
Accession NZ_CP048458
Organism Burkholderia multivorans strain P1Bm2011a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D87_RS19080 Protein ID WP_105758596.1
Coordinates 805371..805826 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D87_RS19075 Protein ID WP_043278882.1
Coordinates 805135..805374 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D87_RS19050 800194..800337 - 144 WP_006409932.1 hypothetical protein -
G0D87_RS19055 800927..801130 + 204 WP_006396646.1 hypothetical protein -
G0D87_RS19060 801144..801827 - 684 WP_006396647.1 Fe2+-dependent dioxygenase -
G0D87_RS19065 801824..802579 - 756 WP_206381805.1 SEL1-like repeat protein -
G0D87_RS19070 802583..804829 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
G0D87_RS19075 805135..805374 + 240 WP_043278882.1 Arc family DNA-binding protein Antitoxin
G0D87_RS19080 805371..805826 + 456 WP_105758596.1 type II toxin-antitoxin system VapC family toxin Toxin
G0D87_RS19085 805923..807218 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
G0D87_RS19090 807451..807585 + 135 WP_059938951.1 entericidin A/B family lipoprotein -
G0D87_RS19095 807680..808255 - 576 WP_105821977.1 permease -
G0D87_RS19100 808451..809401 - 951 WP_105842671.1 DMT family transporter -
G0D87_RS19105 809860..810654 - 795 WP_105777245.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16239.55 Da        Isoelectric Point: 6.4793

>T149536 WP_105758596.1 NZ_CP048458:805371-805826 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPARQGIASK

Download         Length: 456 bp

>T149536 NZ_CP064126:c1890202-1889744 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8738.99 Da        Isoelectric Point: 6.2220

>AT149536 WP_043278882.1 NZ_CP048458:805135-805374 [Burkholderia multivorans]
MPVITVRNLPHEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT149536 NZ_CP064126:c1890710-1890264 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References