Detailed information of TA system TA149533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2434131..2434831
• Replicon: chromosome
• Accession: NZ_CP048457
• Organism: Burkholderia multivorans strain P1Bm2011a

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9B4U7
• Locus tag: G0D87_RS11420
• Protein ID: WP_006398693.1
• Coordinates: 2434131..2434508 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: G0D87_RS11425
• Protein ID: WP_088925506.1
• Coordinates: 2434508..2434831 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D87_RS11395	2429671..2430120	+	450	WP_006413500.1	VOC family protein	-
G0D87_RS11400	2430224..2431774	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
G0D87_RS11405	2431771..2432004	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
G0D87_RS11410	2432201..2433118	-	918	WP_006398696.1	spermidine synthase	-
G0D87_RS11415	2433346..2433600	+	255	WP_035951935.1	hypothetical protein	-
G0D87_RS11420	2434131..2434508	+	378	WP_006398693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D87_RS11425	2434508..2434831	+	324	WP_088925506.1	helix-turn-helix domain-containing protein	Antitoxin
G0D87_RS11430	2434854..2435345	-	492	WP_006398691.1	DNA-deoxyinosine glycosylase	-
G0D87_RS11435	2435342..2435956	-	615	WP_206380652.1	chorismate lyase	-
G0D87_RS11440	2435965..2437863	-	1899	WP_059875776.1	molecular chaperone HtpG	-
G0D87_RS11445	2438023..2439483	-	1461	WP_105780126.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13504.53 Da
• Isoelectric Point: 9.7721

>T149533 WP_006398693.1 NZ_CP048457:2434131-2434508 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Nucleotide

• Length: 378 bp

>T149533 NZ_CP064125:c3473163-3472738 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.83 Da
• Isoelectric Point: 9.1046

>AT149533 WP_088925506.1 NZ_CP048457:2434508-2434831 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPHAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT149533 NZ_CP064125:c3473410-3473144 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: B9B4U7