Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 804084..804775 Replicon chromosome
Accession NZ_CP048455
Organism Burkholderia multivorans strain P1Bm2011b

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D88_RS19065 Protein ID WP_105758596.1
Coordinates 804320..804775 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D88_RS19060 Protein ID WP_043278882.1
Coordinates 804084..804323 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D88_RS19035 799143..799286 - 144 WP_006409932.1 hypothetical protein -
G0D88_RS19040 799876..800079 + 204 WP_006396646.1 hypothetical protein -
G0D88_RS19045 800093..800776 - 684 WP_006396647.1 Fe2+-dependent dioxygenase -
G0D88_RS19050 800773..801528 - 756 WP_206381805.1 SEL1-like repeat protein -
G0D88_RS19055 801532..803778 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
G0D88_RS19060 804084..804323 + 240 WP_043278882.1 Arc family DNA-binding protein Antitoxin
G0D88_RS19065 804320..804775 + 456 WP_105758596.1 type II toxin-antitoxin system VapC family toxin Toxin
G0D88_RS19070 804872..806167 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
G0D88_RS19075 806400..806534 + 135 WP_059938951.1 entericidin A/B family lipoprotein -
G0D88_RS19080 806629..807204 - 576 WP_105821977.1 permease -
G0D88_RS19085 807400..808350 - 951 WP_105842671.1 DMT family transporter -
G0D88_RS19090 808809..809603 - 795 WP_105777245.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16239.55 Da        Isoelectric Point: 6.4793

>T149528 WP_105758596.1 NZ_CP048455:804320-804775 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPARQGIASK

Download         Length: 456 bp

>T149528 NZ_CP064125:c1023029-1022826 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8738.99 Da        Isoelectric Point: 6.2220

>AT149528 WP_043278882.1 NZ_CP048455:804084-804323 [Burkholderia multivorans]
MPVITVRNLPHEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT149528 NZ_CP064125:c1023446-1023078 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References