Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 649168..650458 Replicon chromosome
Accession NZ_CP048455
Organism Burkholderia multivorans strain P1Bm2011b

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D88_RS18450 Protein ID WP_206381764.1
Coordinates 649168..649779 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D88_RS18455 Protein ID WP_206381765.1
Coordinates 649901..650458 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D88_RS18430 644495..645286 + 792 WP_206381925.1 enoyl-CoA hydratase -
G0D88_RS18435 645283..646422 + 1140 WP_206381762.1 enoyl-CoA hydratase/isomerase family protein -
G0D88_RS18440 646469..647389 - 921 WP_006406123.1 LysR family transcriptional regulator -
G0D88_RS18445 647568..649106 + 1539 WP_206381763.1 MFS transporter -
G0D88_RS18450 649168..649779 - 612 WP_206381764.1 HD domain-containing protein Toxin
G0D88_RS18455 649901..650458 - 558 WP_206381765.1 helix-turn-helix domain-containing protein Antitoxin
G0D88_RS18460 650969..652372 + 1404 WP_006396486.1 hypothetical protein -
G0D88_RS18465 652713..653444 + 732 WP_012216547.1 ribonuclease T2 -
G0D88_RS18470 653615..654253 - 639 WP_111310988.1 cysteine hydrolase -
G0D88_RS18475 654382..654918 - 537 Protein_553 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-190)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-51)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22601.32 Da        Isoelectric Point: 5.3228

>T149527 WP_206381764.1 NZ_CP048455:c649779-649168 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALAFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIEAQAQTSSQTQTRTHRT

Download         Length: 612 bp

>T149527 NZ_CP064124:c3664324-3663899 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20363.37 Da        Isoelectric Point: 8.5490

>AT149527 WP_206381765.1 NZ_CP048455:c650458-649901 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRIKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT149527 NZ_CP064124:c3664571-3664305 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References