Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1232919..1233453 Replicon chromosome
Accession NZ_CP048452
Organism Burkholderia multivorans strain P1Bm2012b

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag G0D89_RS20820 Protein ID WP_155825023.1
Coordinates 1232919..1233218 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag G0D89_RS20825 Protein ID WP_006413656.1
Coordinates 1233208..1233453 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D89_RS20805 1229268..1230575 + 1308 WP_039218025.1 shikimate transporter -
G0D89_RS20810 1230610..1231338 - 729 WP_155825024.1 HNH endonuclease -
G0D89_RS20815 1231509..1232810 + 1302 WP_006403538.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
G0D89_RS20820 1232919..1233218 - 300 WP_155825023.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G0D89_RS20825 1233208..1233453 - 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
G0D89_RS20830 1233593..1234363 + 771 WP_006403543.1 helix-turn-helix domain-containing protein -
G0D89_RS20835 1234394..1236694 - 2301 WP_155825022.1 ATP-dependent DNA helicase -
G0D89_RS20840 1236691..1238394 - 1704 WP_206382439.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11542.04 Da        Isoelectric Point: 7.3154

>T149523 WP_155825023.1 NZ_CP048452:c1233218-1232919 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVAFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T149523 NZ_CP064124:c935703-935610 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT149523 WP_006413656.1 NZ_CP048452:c1233453-1233208 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT149523 NZ_CP064124:935609-935703 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References