Detailed information of TA system TA149517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2433201..2433901
• Replicon: chromosome
• Accession: NZ_CP048451
• Organism: Burkholderia multivorans strain P1Bm2012b

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9B4U7
• Locus tag: G0D89_RS11395
• Protein ID: WP_006398693.1
• Coordinates: 2433201..2433578 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: G0D89_RS11400
• Protein ID: WP_088925506.1
• Coordinates: 2433578..2433901 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D89_RS11370	2428741..2429190	+	450	WP_006413500.1	VOC family protein	-
G0D89_RS11375	2429294..2430844	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
G0D89_RS11380	2430841..2431074	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
G0D89_RS11385	2431271..2432188	-	918	WP_006398696.1	spermidine synthase	-
G0D89_RS11390	2432416..2432670	+	255	WP_035951935.1	hypothetical protein	-
G0D89_RS11395	2433201..2433578	+	378	WP_006398693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D89_RS11400	2433578..2433901	+	324	WP_088925506.1	helix-turn-helix domain-containing protein	Antitoxin
G0D89_RS11405	2433924..2434415	-	492	WP_006398691.1	DNA-deoxyinosine glycosylase	-
G0D89_RS11410	2434412..2435026	-	615	WP_206380652.1	chorismate lyase	-
G0D89_RS11415	2435035..2436933	-	1899	WP_059875776.1	molecular chaperone HtpG	-
G0D89_RS11420	2437093..2438553	-	1461	WP_105780126.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13504.53 Da
• Isoelectric Point: 9.7721

>T149517 WP_006398693.1 NZ_CP048451:2433201-2433578 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Nucleotide

• Length: 378 bp

>T149517 NZ_CP064123:c1903846-1903388 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.83 Da
• Isoelectric Point: 9.1046

>AT149517 WP_088925506.1 NZ_CP048451:2433578-2433901 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPHAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT149517 NZ_CP064123:c1904354-1903908 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: B9B4U7