Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2009515..2010135 Replicon chromosome
Accession NZ_CP048449
Organism Burkholderia multivorans strain P1Bm2014

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag G0D90_RS24270 Protein ID WP_012217495.1
Coordinates 2009515..2009832 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag G0D90_RS24275 Protein ID WP_006398012.1
Coordinates 2009836..2010135 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D90_RS24260 2006050..2007483 - 1434 WP_206381418.1 aldehyde dehydrogenase family protein -
G0D90_RS24265 2007512..2009152 - 1641 WP_060040466.1 acetolactate synthase large subunit -
G0D90_RS24270 2009515..2009832 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G0D90_RS24275 2009836..2010135 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
G0D90_RS24280 2010170..2011456 - 1287 WP_039225729.1 DUF445 domain-containing protein -
G0D90_RS24285 2011570..2012790 - 1221 WP_206381419.1 FAD-dependent oxidoreductase -
G0D90_RS24290 2012780..2013106 - 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
G0D90_RS24295 2013124..2013612 - 489 WP_060145122.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
G0D90_RS24300 2013627..2014898 - 1272 WP_206381420.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T149516 WP_012217495.1 NZ_CP048449:2009515-2009832 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T149516 NZ_CP064123:c889529-889326 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT149516 WP_006398012.1 NZ_CP048449:2009836-2010135 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT149516 NZ_CP064123:c889946-889578 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References