Detailed information of TA system TA149515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1233135..1233669
• Replicon: chromosome
• Accession: NZ_CP048449
• Organism: Burkholderia multivorans strain P1Bm2014

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G0D90_RS20835
• Protein ID: WP_155825023.1
• Coordinates: 1233135..1233434 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: J4RB90
• Locus tag: G0D90_RS20840
• Protein ID: WP_006413656.1
• Coordinates: 1233424..1233669 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D90_RS20820	1229484..1230791	+	1308	WP_039218025.1	shikimate transporter	-
G0D90_RS20825	1230826..1231554	-	729	WP_155825024.1	HNH endonuclease	-
G0D90_RS20830	1231725..1233026	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
G0D90_RS20835	1233135..1233434	-	300	WP_155825023.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D90_RS20840	1233424..1233669	-	246	WP_006413656.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G0D90_RS20845	1233809..1234579	+	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
G0D90_RS20850	1234610..1236910	-	2301	WP_155825022.1	ATP-dependent DNA helicase	-
G0D90_RS20855	1236907..1238610	-	1704	WP_206382439.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11542.04 Da
• Isoelectric Point: 7.3154

>T149515 WP_155825023.1 NZ_CP048449:c1233434-1233135 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVAFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T149515 NZ_CP064122:3395683-3395886 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8632.71 Da
• Isoelectric Point: 6.4604

>AT149515 WP_006413656.1 NZ_CP048449:c1233669-1233424 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT149515 NZ_CP064122:3395266-3395634 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3KUX0