Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 930365..932112 Replicon chromosome
Accession NZ_CP048449
Organism Burkholderia multivorans strain P1Bm2014

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G0D90_RS19645 Protein ID WP_048804598.1
Coordinates 930365..931261 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag G0D90_RS19650 Protein ID WP_006396780.1
Coordinates 931258..932112 (+) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D90_RS19615 925765..926844 - 1080 WP_039217461.1 porin -
G0D90_RS19620 927280..927597 + 318 WP_155825139.1 non-heme iron oxygenase ferredoxin subunit -
G0D90_RS19625 927599..927910 + 312 WP_006396775.1 hypothetical protein -
G0D90_RS19630 927958..929028 + 1071 WP_006396776.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
G0D90_RS19635 929021..929791 + 771 WP_006413827.1 SDR family oxidoreductase -
G0D90_RS19640 929819..930346 + 528 WP_006396778.1 cupin domain-containing protein -
G0D90_RS19645 930365..931261 + 897 WP_048804598.1 alpha/beta fold hydrolase Toxin
G0D90_RS19650 931258..932112 + 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
G0D90_RS19655 932109..932906 + 798 WP_155825136.1 SDR family oxidoreductase -
G0D90_RS19660 932899..934566 + 1668 WP_206381835.1 thiamine pyrophosphate-binding protein -
G0D90_RS19665 934559..935389 + 831 WP_006396783.1 aspartate dehydrogenase -
G0D90_RS19670 935451..936941 + 1491 WP_043278809.1 aldehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(51-280)

Antitoxin

(23-71)


Sequences


Toxin        


Download         Length: 299 a.a.        Molecular weight: 30583.83 Da        Isoelectric Point: 8.0534

>T149513 WP_048804598.1 NZ_CP048449:930365-931261 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQHAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA

Download         Length: 897 bp

>T149513 NZ_CP064122:c1823774-1823592 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT149513 WP_006396780.1 NZ_CP048449:931258-932112 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT149513 NZ_CP064122:c1823547-1823128 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References