Detailed information of TA system TA149512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 804209..804900
• Replicon: chromosome
• Accession: NZ_CP048449
• Organism: Burkholderia multivorans strain P1Bm2014

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G0D90_RS19080
• Protein ID: WP_105758596.1
• Coordinates: 804445..804900 (+)
• Length: 152 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G0D90_RS19075
• Protein ID: WP_043278882.1
• Coordinates: 804209..804448 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D90_RS19050	799268..799411	-	144	WP_006409932.1	hypothetical protein	-
G0D90_RS19055	800001..800204	+	204	WP_006396646.1	hypothetical protein	-
G0D90_RS19060	800218..800901	-	684	WP_006396647.1	Fe2+-dependent dioxygenase	-
G0D90_RS19065	800898..801653	-	756	WP_206381805.1	SEL1-like repeat protein	-
G0D90_RS19070	801657..803903	-	2247	WP_012216643.1	TonB-dependent siderophore receptor	-
G0D90_RS19075	804209..804448	+	240	WP_043278882.1	Arc family DNA-binding protein	Antitoxin
G0D90_RS19080	804445..804900	+	456	WP_105758596.1	type II toxin-antitoxin system VapC family toxin	Toxin
G0D90_RS19085	804997..806292	-	1296	WP_035487510.1	aspartate carbamoyltransferase	-
G0D90_RS19090	806525..806659	+	135	WP_059938951.1	entericidin A/B family lipoprotein	-
G0D90_RS19095	806754..807329	-	576	WP_105821977.1	permease	-
G0D90_RS19100	807525..808475	-	951	WP_105842671.1	DMT family transporter	-
G0D90_RS19105	808934..809728	-	795	WP_105777245.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-46)

Sequences

Toxin

Protein

• Length: 152 a.a.
• Molecular weight: 16239.55 Da
• Isoelectric Point: 6.4793

>T149512 WP_105758596.1 NZ_CP048449:804445-804900 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPARQGIASK

Nucleotide

• Length: 456 bp

>T149512 NZ_CP064122:1791104-1791197 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8738.99 Da
• Isoelectric Point: 6.2220

>AT149512 WP_043278882.1 NZ_CP048449:804209-804448 [Burkholderia multivorans]
MPVITVRNLPHEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Nucleotide

• Length: 240 bp

>AT149512 NZ_CP064122:c1791198-1791104 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA