Detailed information of TA system TA149511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 649293..650583
• Replicon: chromosome
• Accession: NZ_CP048449
• Organism: Burkholderia multivorans strain P1Bm2014

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G0D90_RS18465
• Protein ID: WP_206381764.1
• Coordinates: 649293..649904 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G0D90_RS18470
• Protein ID: WP_206381765.1
• Coordinates: 650026..650583 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D90_RS18445	644620..645411	+	792	WP_206381925.1	enoyl-CoA hydratase	-
G0D90_RS18450	645408..646547	+	1140	WP_206381762.1	enoyl-CoA hydratase/isomerase family protein	-
G0D90_RS18455	646594..647514	-	921	WP_006406123.1	LysR family transcriptional regulator	-
G0D90_RS18460	647693..649231	+	1539	WP_206381763.1	MFS transporter	-
G0D90_RS18465	649293..649904	-	612	WP_206381764.1	HD domain-containing protein	Toxin
G0D90_RS18470	650026..650583	-	558	WP_206381765.1	helix-turn-helix domain-containing protein	Antitoxin
G0D90_RS18475	651094..652497	+	1404	WP_006396486.1	hypothetical protein	-
G0D90_RS18480	652838..653569	+	732	WP_012216547.1	ribonuclease T2	-
G0D90_RS18485	653740..654378	-	639	WP_111310988.1	cysteine hydrolase	-
G0D90_RS18490	654507..655043	-	537	Protein_553	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-190)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-51)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22601.32 Da
• Isoelectric Point: 5.3228

>T149511 WP_206381764.1 NZ_CP048449:c649904-649293 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALAFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIEAQAQTSSQTQTRTHRT

Nucleotide

• Length: 612 bp

>T149511 NZ_CP064122:976643-976939 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20363.37 Da
• Isoelectric Point: 8.5490

>AT149511 WP_206381765.1 NZ_CP048449:c650583-650026 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRIKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT149511 NZ_CP064122:976939-977337 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG