Detailed information of TA system TA149509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2434171..2434871
• Replicon: chromosome
• Accession: NZ_CP048448
• Organism: Burkholderia multivorans strain P1Bm2014

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9B4U7
• Locus tag: G0D90_RS11410
• Protein ID: WP_006398693.1
• Coordinates: 2434171..2434548 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: G0D90_RS11415
• Protein ID: WP_088925506.1
• Coordinates: 2434548..2434871 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D90_RS11385	2429711..2430160	+	450	WP_006413500.1	VOC family protein	-
G0D90_RS11390	2430264..2431814	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
G0D90_RS11395	2431811..2432044	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
G0D90_RS11400	2432241..2433158	-	918	WP_006398696.1	spermidine synthase	-
G0D90_RS11405	2433386..2433640	+	255	WP_035951935.1	hypothetical protein	-
G0D90_RS11410	2434171..2434548	+	378	WP_006398693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D90_RS11415	2434548..2434871	+	324	WP_088925506.1	helix-turn-helix domain-containing protein	Antitoxin
G0D90_RS11420	2434894..2435385	-	492	WP_006398691.1	DNA-deoxyinosine glycosylase	-
G0D90_RS11425	2435382..2435996	-	615	WP_206380652.1	chorismate lyase	-
G0D90_RS11430	2436005..2437903	-	1899	WP_059875776.1	molecular chaperone HtpG	-
G0D90_RS11435	2438063..2439523	-	1461	WP_105780126.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13504.53 Da
• Isoelectric Point: 9.7721

>T149509 WP_006398693.1 NZ_CP048448:2434171-2434548 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Nucleotide

• Length: 378 bp

>T149509 NZ_CP064121:c3056923-3056498 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.83 Da
• Isoelectric Point: 9.1046

>AT149509 WP_088925506.1 NZ_CP048448:2434548-2434871 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPHAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT149509 NZ_CP064121:c3057170-3056904 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: B9B4U7