Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 804787..805478 Replicon chromosome
Accession NZ_CP048446
Organism Burkholderia multivorans strain P1Bm2015

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D91_RS19090 Protein ID WP_105758596.1
Coordinates 805023..805478 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D91_RS19085 Protein ID WP_043278882.1
Coordinates 804787..805026 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D91_RS19060 799846..799989 - 144 WP_006409932.1 hypothetical protein -
G0D91_RS19065 800579..800782 + 204 WP_006396646.1 hypothetical protein -
G0D91_RS19070 800796..801479 - 684 WP_006396647.1 Fe2+-dependent dioxygenase -
G0D91_RS19075 801476..802231 - 756 WP_206381805.1 SEL1-like repeat protein -
G0D91_RS19080 802235..804481 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
G0D91_RS19085 804787..805026 + 240 WP_043278882.1 Arc family DNA-binding protein Antitoxin
G0D91_RS19090 805023..805478 + 456 WP_105758596.1 type II toxin-antitoxin system VapC family toxin Toxin
G0D91_RS19095 805575..806870 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
G0D91_RS19100 807103..807237 + 135 WP_059938951.1 entericidin A/B family lipoprotein -
G0D91_RS19105 807332..807907 - 576 WP_105821977.1 permease -
G0D91_RS19110 808103..809053 - 951 WP_105842671.1 DMT family transporter -
G0D91_RS19115 809512..810306 - 795 WP_105777245.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16239.55 Da        Isoelectric Point: 6.4793

>T149504 WP_105758596.1 NZ_CP048446:805023-805478 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPARQGIASK

Download         Length: 456 bp

>T149504 NZ_CP064121:c620082-619879 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8738.99 Da        Isoelectric Point: 6.2220

>AT149504 WP_043278882.1 NZ_CP048446:804787-805026 [Burkholderia multivorans]
MPVITVRNLPHEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT149504 NZ_CP064121:c620499-620131 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References