Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 649871..651161 Replicon chromosome
Accession NZ_CP048446
Organism Burkholderia multivorans strain P1Bm2015

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D91_RS18475 Protein ID WP_206381764.1
Coordinates 649871..650482 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D91_RS18480 Protein ID WP_206381765.1
Coordinates 650604..651161 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D91_RS18455 645198..645989 + 792 WP_206381925.1 enoyl-CoA hydratase -
G0D91_RS18460 645986..647125 + 1140 WP_206381762.1 enoyl-CoA hydratase/isomerase family protein -
G0D91_RS18465 647172..648092 - 921 WP_006406123.1 LysR family transcriptional regulator -
G0D91_RS18470 648271..649809 + 1539 WP_206381763.1 MFS transporter -
G0D91_RS18475 649871..650482 - 612 WP_206381764.1 HD domain-containing protein Toxin
G0D91_RS18480 650604..651161 - 558 WP_206381765.1 helix-turn-helix domain-containing protein Antitoxin
G0D91_RS18485 651672..653075 + 1404 WP_006396486.1 hypothetical protein -
G0D91_RS18490 653416..654147 + 732 WP_012216547.1 ribonuclease T2 -
G0D91_RS18495 654318..654956 - 639 WP_111310988.1 cysteine hydrolase -
G0D91_RS18500 655085..655621 - 537 Protein_552 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-190)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-51)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22601.32 Da        Isoelectric Point: 5.3228

>T149503 WP_206381764.1 NZ_CP048446:c650482-649871 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALAFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIEAQAQTSSQTQTRTHRT

Download         Length: 612 bp

>T149503 NZ_CP064120:3232577-3232780 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20363.37 Da        Isoelectric Point: 8.5490

>AT149503 WP_206381765.1 NZ_CP048446:c651161-650604 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRIKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT149503 NZ_CP064120:3232160-3232528 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References