Detailed information of TA system TA149501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2435405..2436105
• Replicon: chromosome
• Accession: NZ_CP048445
• Organism: Burkholderia multivorans strain P1Bm2015

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9B4U7
• Locus tag: G0D91_RS11425
• Protein ID: WP_006398693.1
• Coordinates: 2435405..2435782 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: G0D91_RS11430
• Protein ID: WP_088925506.1
• Coordinates: 2435782..2436105 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D91_RS11400	2430945..2431394	+	450	WP_006413500.1	VOC family protein	-
G0D91_RS11405	2431498..2433048	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
G0D91_RS11410	2433045..2433278	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
G0D91_RS11415	2433475..2434392	-	918	WP_006398696.1	spermidine synthase	-
G0D91_RS11420	2434620..2434874	+	255	WP_035951935.1	hypothetical protein	-
G0D91_RS11425	2435405..2435782	+	378	WP_006398693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D91_RS11430	2435782..2436105	+	324	WP_088925506.1	helix-turn-helix domain-containing protein	Antitoxin
G0D91_RS11435	2436128..2436619	-	492	WP_006398691.1	DNA-deoxyinosine glycosylase	-
G0D91_RS11440	2436616..2437230	-	615	WP_206380652.1	chorismate lyase	-
G0D91_RS11445	2437239..2439137	-	1899	WP_059875776.1	molecular chaperone HtpG	-
G0D91_RS11450	2439297..2440757	-	1461	WP_105780126.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13504.53 Da
• Isoelectric Point: 9.7721

>T149501 WP_006398693.1 NZ_CP048445:2435405-2435782 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Nucleotide

• Length: 378 bp

>T149501 NZ_CP064120:2857520-2857702 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.83 Da
• Isoelectric Point: 9.1046

>AT149501 WP_088925506.1 NZ_CP048445:2435782-2436105 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPHAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT149501 NZ_CP064120:2857747-2858166 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Structures

Toxin

• AlphaFold DB: B9B4U7