Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 120829..121475 Replicon plasmid unnamed
Accession NZ_CP048444
Organism Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D92_RS30000 Protein ID WP_012211060.1
Coordinates 121068..121475 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D92_RS29995 Protein ID WP_009692911.1
Coordinates 120829..121071 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D92_RS29975 115966..116823 - 858 WP_012211056.1 replication initiator protein A -
G0D92_RS29980 117566..118531 - 966 WP_012211057.1 ParB/RepB/Spo0J family partition protein -
G0D92_RS29985 118531..119202 - 672 WP_206382236.1 AAA family ATPase -
G0D92_RS29990 119697..120727 + 1031 Protein_107 non-homologous end-joining DNA ligase -
G0D92_RS29995 120829..121071 + 243 WP_009692911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G0D92_RS30000 121068..121475 + 408 WP_012211060.1 type II toxin-antitoxin system VapC family toxin Toxin
G0D92_RS30005 121819..122139 + 321 WP_105839319.1 hypothetical protein -
G0D92_RS30010 122243..122779 + 537 WP_105839318.1 hypothetical protein -
G0D92_RS30015 122821..123057 + 237 Protein_112 hypothetical protein -
G0D92_RS30020 123054..123785 + 732 WP_105839315.1 hypothetical protein -
G0D92_RS30025 123787..126123 + 2337 WP_105839314.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..161953 161953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14613.77 Da        Isoelectric Point: 5.1402

>T149500 WP_012211060.1 NZ_CP048444:121068-121475 [Burkholderia multivorans]
MSLYLLDTNILSNVIRDPRGACASRIGETRPEQVCTSIVVAAELRYGVCKRGSSALAQRVEQLLASLTVLPLQSDADQCY
GRLRADLERQGQLIGANDMLIAAHAMAVDAVLVTDNTAEFTRVTGLAVENWLRPA

Download         Length: 408 bp

>T149500 NZ_CP064120:2667178-2667636 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9309.54 Da        Isoelectric Point: 4.8615

>AT149500 WP_009692911.1 NZ_CP048444:120829-121071 [Burkholderia multivorans]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAPSLRELFAQWAPLDETFPDIENLPAEPVDIE

Download         Length: 243 bp

>AT149500 NZ_CP064120:2666670-2667116 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References