Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1988799..1989419 Replicon chromosome
Accession NZ_CP048442
Organism Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag G0D92_RS24450 Protein ID WP_012217495.1
Coordinates 1988799..1989116 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag G0D92_RS24455 Protein ID WP_006398012.1
Coordinates 1989120..1989419 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D92_RS24440 1985334..1986767 - 1434 WP_206381418.1 aldehyde dehydrogenase family protein -
G0D92_RS24445 1986796..1988436 - 1641 WP_060040466.1 acetolactate synthase large subunit -
G0D92_RS24450 1988799..1989116 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G0D92_RS24455 1989120..1989419 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
G0D92_RS24460 1989454..1990740 - 1287 WP_039225729.1 DUF445 domain-containing protein -
G0D92_RS24465 1990854..1992074 - 1221 WP_206381419.1 FAD-dependent oxidoreductase -
G0D92_RS24470 1992064..1992390 - 327 WP_006404219.1 non-heme iron oxygenase ferredoxin subunit -
G0D92_RS24475 1992408..1992896 - 489 WP_060145122.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
G0D92_RS24480 1992911..1994182 - 1272 WP_206381420.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T149499 WP_012217495.1 NZ_CP048442:1988799-1989116 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T149499 NZ_CP064120:916095-916391 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT149499 WP_006398012.1 NZ_CP048442:1989120-1989419 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT149499 NZ_CP064120:916391-916789 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References