Detailed information of TA system TA149498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1244033..1244567
• Replicon: chromosome
• Accession: NZ_CP048442
• Organism: Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G0D92_RS21225
• Protein ID: WP_155825023.1
• Coordinates: 1244033..1244332 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: J4RB90
• Locus tag: G0D92_RS21230
• Protein ID: WP_006413656.1
• Coordinates: 1244322..1244567 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D92_RS21210	1240382..1241689	+	1308	WP_039218025.1	shikimate transporter	-
G0D92_RS21215	1241724..1242452	-	729	WP_155825024.1	HNH endonuclease	-
G0D92_RS21220	1242623..1243924	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
G0D92_RS21225	1244033..1244332	-	300	WP_155825023.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D92_RS21230	1244322..1244567	-	246	WP_006413656.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G0D92_RS21235	1244707..1245477	+	771	WP_006403543.1	helix-turn-helix domain-containing protein	-
G0D92_RS21240	1245508..1247808	-	2301	WP_155825022.1	ATP-dependent DNA helicase	-
G0D92_RS21245	1247805..1249508	-	1704	WP_206381193.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11542.04 Da
• Isoelectric Point: 7.3154

>T149498 WP_155825023.1 NZ_CP048442:c1244332-1244033 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVAFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T149498 NZ_CP064120:901685-902110 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8632.71 Da
• Isoelectric Point: 6.4604

>AT149498 WP_006413656.1 NZ_CP048442:c1244567-1244322 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT149498 NZ_CP064120:901438-901704 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3KUX0