Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 814415..815106 Replicon chromosome
Accession NZ_CP048442
Organism Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D92_RS19450 Protein ID WP_105758596.1
Coordinates 814651..815106 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D92_RS19445 Protein ID WP_043278882.1
Coordinates 814415..814654 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D92_RS19420 809474..809617 - 144 WP_006409932.1 hypothetical protein -
G0D92_RS19425 810207..810410 + 204 WP_006396646.1 hypothetical protein -
G0D92_RS19430 810424..811107 - 684 WP_006396647.1 Fe2+-dependent dioxygenase -
G0D92_RS19435 811104..811859 - 756 WP_206381805.1 SEL1-like repeat protein -
G0D92_RS19440 811863..814109 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
G0D92_RS19445 814415..814654 + 240 WP_043278882.1 Arc family DNA-binding protein Antitoxin
G0D92_RS19450 814651..815106 + 456 WP_105758596.1 type II toxin-antitoxin system VapC family toxin Toxin
G0D92_RS19455 815203..816498 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
G0D92_RS19460 816731..816865 + 135 WP_059938951.1 entericidin A/B family lipoprotein -
G0D92_RS19465 816960..817535 - 576 WP_105821977.1 permease -
G0D92_RS19470 817731..818681 - 951 WP_105842671.1 DMT family transporter -
G0D92_RS19475 819140..819934 - 795 WP_105777245.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16239.55 Da        Isoelectric Point: 6.4793

>T149495 WP_105758596.1 NZ_CP048442:814651-815106 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPARQGIASK

Download         Length: 456 bp

>T149495 NZ_CP064119:c2182139-2181957 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8738.99 Da        Isoelectric Point: 6.2220

>AT149495 WP_043278882.1 NZ_CP048442:814415-814654 [Burkholderia multivorans]
MPVITVRNLPHEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT149495 NZ_CP064119:c2181912-2181493 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References