Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 657023..658313 Replicon chromosome
Accession NZ_CP048442
Organism Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G0D92_RS18820 Protein ID WP_206381764.1
Coordinates 657023..657634 (-) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G0D92_RS18825 Protein ID WP_206381765.1
Coordinates 657756..658313 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G0D92_RS18800 652350..653141 + 792 WP_206381925.1 enoyl-CoA hydratase -
G0D92_RS18805 653138..654277 + 1140 WP_206381762.1 enoyl-CoA hydratase/isomerase family protein -
G0D92_RS18810 654324..655244 - 921 WP_006406123.1 LysR family transcriptional regulator -
G0D92_RS18815 655423..656961 + 1539 WP_206381763.1 MFS transporter -
G0D92_RS18820 657023..657634 - 612 WP_206381764.1 HD domain-containing protein Toxin
G0D92_RS18825 657756..658313 - 558 WP_206381765.1 helix-turn-helix domain-containing protein Antitoxin
G0D92_RS18830 658824..660227 + 1404 WP_006396486.1 hypothetical protein -
G0D92_RS18835 660568..661299 + 732 WP_012216547.1 ribonuclease T2 -
G0D92_RS18840 661470..662108 - 639 WP_111310988.1 cysteine hydrolase -
G0D92_RS18845 662237..662773 - 537 Protein_558 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-190)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-51)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22601.32 Da        Isoelectric Point: 5.3228

>T149494 WP_206381764.1 NZ_CP048442:c657634-657023 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALAFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIEAQAQTSSQTQTRTHRT

Download         Length: 612 bp

>T149494 NZ_CP064119:2149469-2149562 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20363.37 Da        Isoelectric Point: 8.5490

>AT149494 WP_206381765.1 NZ_CP048442:c658313-657756 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRIKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT149494 NZ_CP064119:c2149563-2149469 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References