Detailed information of TA system TA149494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 657023..658313
• Replicon: chromosome
• Accession: NZ_CP048442
• Organism: Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G0D92_RS18820
• Protein ID: WP_206381764.1
• Coordinates: 657023..657634 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G0D92_RS18825
• Protein ID: WP_206381765.1
• Coordinates: 657756..658313 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D92_RS18800	652350..653141	+	792	WP_206381925.1	enoyl-CoA hydratase	-
G0D92_RS18805	653138..654277	+	1140	WP_206381762.1	enoyl-CoA hydratase/isomerase family protein	-
G0D92_RS18810	654324..655244	-	921	WP_006406123.1	LysR family transcriptional regulator	-
G0D92_RS18815	655423..656961	+	1539	WP_206381763.1	MFS transporter	-
G0D92_RS18820	657023..657634	-	612	WP_206381764.1	HD domain-containing protein	Toxin
G0D92_RS18825	657756..658313	-	558	WP_206381765.1	helix-turn-helix domain-containing protein	Antitoxin
G0D92_RS18830	658824..660227	+	1404	WP_006396486.1	hypothetical protein	-
G0D92_RS18835	660568..661299	+	732	WP_012216547.1	ribonuclease T2	-
G0D92_RS18840	661470..662108	-	639	WP_111310988.1	cysteine hydrolase	-
G0D92_RS18845	662237..662773	-	537	Protein_558	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-190)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-51)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22601.32 Da
• Isoelectric Point: 5.3228

>T149494 WP_206381764.1 NZ_CP048442:c657634-657023 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALAFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIEAQAQTSSQTQTRTHRT

Nucleotide

• Length: 612 bp

>T149494 NZ_CP064119:2149469-2149562 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20363.37 Da
• Isoelectric Point: 8.5490

>AT149494 WP_206381765.1 NZ_CP048442:c658313-657756 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRIKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT149494 NZ_CP064119:c2149563-2149469 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA