Detailed information of TA system TA149493

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 329819..330414
• Replicon: chromosome
• Accession: NZ_CP048442
• Organism: Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: G0D92_RS17405
• Protein ID: WP_206381685.1
• Coordinates: 329819..330169 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: A0A2S9MLU5
• Locus tag: G0D92_RS17410
• Protein ID: WP_059843544.1
• Coordinates: 330163..330414 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D92_RS17395	324908..328093	+	3186	WP_059786902.1	multidrug efflux RND transporter permease subunit CeoB	-
G0D92_RS17400	328104..329639	+	1536	WP_039223192.1	multidrug efflux transporter outer membrane subunit OpcM	-
G0D92_RS17405	329819..330169	-	351	WP_206381685.1	type II toxin-antitoxin system ChpB family toxin	Toxin
G0D92_RS17410	330163..330414	-	252	WP_059843544.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
G0D92_RS17415	330542..332035	-	1494	WP_206381686.1	M81 family metallopeptidase	-
G0D92_RS17420	332135..333439	-	1305	WP_206381687.1	MFS transporter	-
G0D92_RS17425	333581..334552	+	972	WP_206381688.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12354.35 Da
• Isoelectric Point: 7.9957

>T149493 WP_206381685.1 NZ_CP048442:c330169-329819 [Burkholderia multivorans]
MVKRVKFERGDIVRVSPNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGECARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Nucleotide

• Length: 351 bp

>T149493 NZ_CP064119:c1466625-1466329 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9021.38 Da
• Isoelectric Point: 6.2518

>AT149493 WP_059843544.1 NZ_CP048442:c330414-330163 [Burkholderia multivorans]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDELVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Nucleotide

• Length: 252 bp

>AT149493 NZ_CP064119:c1466329-1465931 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: A0A2S9MLU5