Detailed information of TA system TA149492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2520396..2521096
• Replicon: chromosome
• Accession: NZ_CP048441
• Organism: Burkholderia multivorans strain P2Bm2011a

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9B4U7
• Locus tag: G0D92_RS11735
• Protein ID: WP_006398693.1
• Coordinates: 2520396..2520773 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: G0D92_RS11740
• Protein ID: WP_088925506.1
• Coordinates: 2520773..2521096 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G0D92_RS11710	2515936..2516385	+	450	WP_006413500.1	VOC family protein	-
G0D92_RS11715	2516489..2518039	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
G0D92_RS11720	2518036..2518269	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
G0D92_RS11725	2518466..2519383	-	918	WP_006398696.1	spermidine synthase	-
G0D92_RS11730	2519611..2519865	+	255	WP_035951935.1	hypothetical protein	-
G0D92_RS11735	2520396..2520773	+	378	WP_006398693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G0D92_RS11740	2520773..2521096	+	324	WP_088925506.1	helix-turn-helix domain-containing protein	Antitoxin
G0D92_RS11745	2521119..2521610	-	492	WP_006398691.1	DNA-deoxyinosine glycosylase	-
G0D92_RS11750	2521607..2522221	-	615	WP_206380652.1	chorismate lyase	-
G0D92_RS11755	2522230..2524128	-	1899	WP_059875776.1	molecular chaperone HtpG	-
G0D92_RS11760	2524288..2525748	-	1461	WP_105780126.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13504.53 Da
• Isoelectric Point: 9.7721

>T149492 WP_006398693.1 NZ_CP048441:2520396-2520773 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGGK

Nucleotide

• Length: 378 bp

>T149492 NZ_CP064119:c1168087-1167662 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11864.83 Da
• Isoelectric Point: 9.1046

>AT149492 WP_088925506.1 NZ_CP048441:2520773-2521096 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPHAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHTEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT149492 NZ_CP064119:c1168334-1168068 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: B9B4U7