Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1717252..1717817 Replicon chromosome
Accession NZ_CP048437
Organism Faecalibacterium prausnitzii A2-165 strain JCM 31915

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag GXM22_RS08340 Protein ID WP_002596328.1
Coordinates 1717527..1717817 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag GXM22_RS08335 Protein ID WP_005924829.1
Coordinates 1717252..1717530 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXM22_RS08300 1713415..1713861 + 447 WP_005933531.1 hypothetical protein -
GXM22_RS08305 1713901..1714215 + 315 WP_050762801.1 hypothetical protein -
GXM22_RS08310 1714323..1714688 - 366 WP_014080225.1 hypothetical protein -
GXM22_RS08315 1714766..1714960 - 195 WP_005933543.1 transposon-encoded TnpW family protein -
GXM22_RS08320 1715004..1715867 - 864 WP_005933545.1 ATP-binding protein -
GXM22_RS08325 1715864..1716613 - 750 WP_005933547.1 phage replisome organizer N-terminal domain-containing protein -
GXM22_RS08330 1716727..1717125 - 399 WP_005933550.1 cysteine-rich VLP domain-containing protein -
GXM22_RS08335 1717252..1717530 + 279 WP_005924829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GXM22_RS08340 1717527..1717817 + 291 WP_002596328.1 type II toxin-antitoxin system YafQ family toxin Toxin
GXM22_RS08345 1717925..1719370 - 1446 WP_007037415.1 MobA/MobL family protein -
GXM22_RS08350 1719557..1719847 - 291 WP_005933556.1 DUF3847 domain-containing protein -
GXM22_RS08355 1719876..1720337 - 462 WP_035394327.1 sigma-70 family RNA polymerase sigma factor -
GXM22_RS08360 1720348..1720800 - 453 WP_005933558.1 hypothetical protein -
GXM22_RS08365 1720904..1721317 - 414 WP_035394329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1714323..1730641 16318


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T149452 WP_002596328.1 NZ_CP048437:1717527-1717817 [Faecalibacterium prausnitzii A2-165]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T149452 NZ_CP064103:c4726850-4726677 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT149452 WP_005924829.1 NZ_CP048437:1717252-1717530 [Faecalibacterium prausnitzii A2-165]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT149452 NZ_CP064103:c4727174-4726878 [Escherichia coli]
ATGGAAGGTAAAAATAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4XBM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4XB19

References