Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxT-higA/Tad-HTH_37
Location 1282719..1283356 Replicon chromosome
Accession NZ_CP048437
Organism Faecalibacterium prausnitzii A2-165 strain JCM 31915

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag GXM22_RS06205 Protein ID WP_099357206.1
Coordinates 1282719..1283078 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GXM22_RS06210 Protein ID WP_035394514.1
Coordinates 1283075..1283356 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GXM22_RS06180 1278227..1280080 + 1854 WP_035394516.1 polysaccharide biosynthesis protein -
GXM22_RS06185 1280255..1281550 + 1296 WP_035394396.1 diaminopimelate decarboxylase -
GXM22_RS06190 1281579..1281977 + 399 WP_005933883.1 hypothetical protein -
GXM22_RS06195 1282124..1282465 + 342 WP_005933882.1 hypothetical protein -
GXM22_RS06205 1282719..1283078 + 360 WP_099357206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GXM22_RS06210 1283075..1283356 + 282 WP_035394514.1 helix-turn-helix domain-containing protein Antitoxin
GXM22_RS06215 1283521..1284231 + 711 WP_005933880.1 UMP kinase -
GXM22_RS06220 1284319..1284873 + 555 WP_005933879.1 ribosome recycling factor -
GXM22_RS06225 1284986..1285699 + 714 WP_035394393.1 di-trans,poly-cis-decaprenylcistransferase -
GXM22_RS06230 1285730..1286590 + 861 WP_005933875.1 phosphatidate cytidylyltransferase -
GXM22_RS06235 1286607..1287758 + 1152 WP_099357205.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-82)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13724.79 Da        Isoelectric Point: 9.2962

>T149451 WP_099357206.1 NZ_CP048437:1282719-1283078 [Faecalibacterium prausnitzii A2-165]
VQEYEIEFYDKADGSEPAKEFILALDAKMRAKVVRTVGLLREEGPSLREPYSKHLEDGIFEIRTKFGSDITRVLYFFVIG
RRIILTNGFVKKTQKTPASEIALAKQYRADYLSRKECSQ

Download         Length: 360 bp

>T149451 NZ_CP064103:c4625299-4624949 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10424.87 Da        Isoelectric Point: 4.8279

>AT149451 WP_035394514.1 NZ_CP048437:1283075-1283356 [Faecalibacterium prausnitzii A2-165]
MTNFNDFLNEQMKDPEFKAEWDALDPEFAVIEAILAARKESGLTQQQLSERTGIAQTDISKLERGNGNPSLRTLQRLAAG
MGMRVKIEFVPAK

Download         Length: 282 bp

>AT149451 NZ_CP064103:c4625544-4625293 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References