Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2633346..2633860 Replicon chromosome
Accession NZ_CP048431
Organism Staphylococcus aureus strain SA1428

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag GZ067_RS12935 Protein ID WP_000581792.1
Coordinates 2633651..2633860 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag GZ067_RS12930 Protein ID WP_000138932.1
Coordinates 2633346..2633639 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ067_RS12905 2628817..2629458 + 642 WP_000483153.1 thiamine phosphate synthase -
GZ067_RS12910 2629544..2630416 + 873 WP_164026389.1 membrane protein insertase YidC -
GZ067_RS12920 2631021..2631668 - 648 WP_164026391.1 HD domain-containing protein -
GZ067_RS12925 2631696..2633180 - 1485 WP_000571549.1 cardiolipin synthase -
GZ067_RS12930 2633346..2633639 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
GZ067_RS12935 2633651..2633860 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
GZ067_RS12940 2633988..2634125 + 138 WP_000828354.1 hypothetical protein -
GZ067_RS12945 2634389..2635591 - 1203 WP_001109939.1 rod shape-determining protein RodA -
GZ067_RS12950 2635909..2636979 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
GZ067_RS12955 2636994..2638352 + 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T149446 WP_000581792.1 NZ_CP048431:2633651-2633860 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T149446 NZ_CP064103:c3860196-3859894 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCTGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT149446 WP_000138932.1 NZ_CP048431:2633346-2633639 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT149446 NZ_CP064103:c3859858-3859517 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References