Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1152331..1152808 Replicon chromosome
Accession NZ_CP048431
Organism Staphylococcus aureus strain SA1428

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GZ067_RS05725 Protein ID WP_000052076.1
Coordinates 1152620..1152808 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GZ067_RS05720 Protein ID WP_001059690.1
Coordinates 1152331..1152591 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ067_RS05685 1147724..1148440 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
GZ067_RS05690 1148588..1149010 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
GZ067_RS05695 1149409..1149903 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
GZ067_RS05700 1150058..1150675 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
GZ067_RS05705 1150748..1151329 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
GZ067_RS05710 1151554..1151790 + 237 WP_000368687.1 hypothetical protein -
GZ067_RS05715 1151787..1151990 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GZ067_RS05720 1152331..1152591 + 261 WP_001059690.1 hypothetical protein Antitoxin
GZ067_RS05725 1152620..1152808 + 189 WP_000052076.1 hypothetical protein Toxin
GZ067_RS05730 1152996..1153565 + 570 WP_001106653.1 hypothetical protein -
GZ067_RS05735 1153653..1153937 + 285 WP_001004394.1 hypothetical protein -
GZ067_RS05740 1153999..1154217 + 219 WP_000005884.1 hypothetical protein -
GZ067_RS05745 1154742..1156061 + 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
GZ067_RS05750 1156233..1156433 - 201 WP_001059082.1 cold-shock protein -
GZ067_RS05755 1156790..1157476 - 687 WP_001548082.1 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1154742..1156061 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T149441 WP_000052076.1 NZ_CP048431:1152620-1152808 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T149441 NZ_CP064103:2325468-2325571 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT149441 WP_001059690.1 NZ_CP048431:1152331-1152591 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT149441 NZ_CP064103:c2325609-2325338 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References