Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5442575..5443091 Replicon chromosome
Accession NZ_CP048430
Organism Klebsiella pneumoniae strain KP18-3-8

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag GZ213_RS27570 Protein ID WP_002886902.1
Coordinates 5442807..5443091 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag GZ213_RS27565 Protein ID WP_002886901.1
Coordinates 5442575..5442817 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ213_RS27550 5438604..5439344 + 741 WP_002886899.1 KDGP aldolase family protein -
GZ213_RS27555 5439410..5440564 + 1155 WP_002886900.1 lactonase family protein -
GZ213_RS27560 5440587..5442497 + 1911 WP_004152270.1 BglG family transcription antiterminator -
GZ213_RS27565 5442575..5442817 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GZ213_RS27570 5442807..5443091 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZ213_RS27575 5443095..5443559 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GZ213_RS27580 5443800..5445938 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
GZ213_RS27585 5446295..5447038 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
GZ213_RS27590 5447041..5447214 - 174 WP_002886906.1 hypothetical protein -
GZ213_RS27595 5447299..5447607 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T149435 WP_002886902.1 NZ_CP048430:5442807-5443091 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T149435 NZ_CP064103:228590-228697 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT149435 WP_002886901.1 NZ_CP048430:5442575-5442817 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT149435 NZ_CP064103:c228533-228478 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References