Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2114655..2116243 Replicon chromosome
Accession NZ_CP048430
Organism Klebsiella pneumoniae strain KP18-3-8

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag GZ213_RS10805 Protein ID WP_004199851.1
Coordinates 2114921..2116243 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag GZ213_RS10800 Protein ID WP_002904790.1
Coordinates 2114655..2114921 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ213_RS10775 2109805..2110728 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
GZ213_RS10780 2110709..2111863 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
GZ213_RS10785 2112209..2113588 + 1380 WP_004199850.1 purine permease -
GZ213_RS10790 2113566..2114066 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
GZ213_RS10795 2114063..2114389 + 327 WP_002904788.1 hydroxyisourate hydrolase -
GZ213_RS10800 2114655..2114921 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GZ213_RS10805 2114921..2116243 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
GZ213_RS10810 2116260..2117552 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
GZ213_RS10815 2117685..2118689 - 1005 WP_004199852.1 type 1 fimbrial protein -
GZ213_RS10820 2118677..2121178 - 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T149420 WP_004199851.1 NZ_CP048430:2114921-2116243 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T149420 NZ_CP064095:3955006-3955182 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT149420 WP_002904790.1 NZ_CP048430:2114655-2114921 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT149420 NZ_CP064095:c3955223-3955123 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References