Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 611666..612285 Replicon chromosome
Accession NZ_CP048430
Organism Klebsiella pneumoniae strain KP18-3-8

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GZ213_RS03010 Protein ID WP_002892050.1
Coordinates 611666..611884 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GZ213_RS03015 Protein ID WP_002892066.1
Coordinates 611911..612285 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ213_RS02975 607713..607976 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
GZ213_RS02980 607976..608116 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GZ213_RS02985 608113..608811 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
GZ213_RS02990 608912..610363 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GZ213_RS02995 610338..610808 - 471 WP_002892026.1 YlaC family protein -
GZ213_RS03000 610829..610969 + 141 WP_004147370.1 hypothetical protein -
GZ213_RS03005 610941..611507 - 567 WP_002892030.1 maltose O-acetyltransferase -
GZ213_RS03010 611666..611884 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GZ213_RS03015 611911..612285 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GZ213_RS03020 612771..615917 - 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
GZ213_RS03025 615940..617133 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T149419 WP_002892050.1 NZ_CP048430:c611884-611666 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T149419 NZ_CP064095:3955006-3955182 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT149419 WP_002892066.1 NZ_CP048430:c612285-611911 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT149419 NZ_CP064095:c3955065-3954965 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References