Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3367001..3367606 Replicon chromosome
Accession NZ_CP048429
Organism Paenibacillus jilunlii strain KACC 16679

Toxin (Protein)


Gene name mazF Uniprot ID A0A0E4H7G2
Locus tag GT351_RS14880 Protein ID WP_019913013.1
Coordinates 3367256..3367606 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GT351_RS14875 Protein ID WP_174469047.1
Coordinates 3367001..3367252 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT351_RS14860 3363196..3364032 + 837 WP_062519618.1 methyl-accepting chemotaxis protein -
GT351_RS14865 3364270..3365355 + 1086 WP_062519614.1 outer membrane lipoprotein carrier protein LolA -
GT351_RS14870 3365578..3366759 + 1182 WP_062519611.1 alanine racemase -
GT351_RS14875 3367001..3367252 + 252 WP_174469047.1 ribbon-helix-helix protein, CopG family Antitoxin
GT351_RS14880 3367256..3367606 + 351 WP_019913013.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GT351_RS14885 3368021..3369331 + 1311 WP_062519675.1 extracellular solute-binding protein -
GT351_RS14890 3369440..3370324 + 885 WP_062519608.1 sugar ABC transporter permease -
GT351_RS14895 3370327..3371154 + 828 WP_062519606.1 carbohydrate ABC transporter permease -
GT351_RS14900 3371180..3371998 + 819 WP_062519605.1 carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12749.67 Da        Isoelectric Point: 4.8265

>T149418 WP_019913013.1 NZ_CP048429:3367256-3367606 [Paenibacillus jilunlii]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKLVDDSLQISLGLIDF

Download         Length: 351 bp

>T149418 NZ_CP064095:c3901372-3901256 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9487.94 Da        Isoelectric Point: 5.1051

>AT149418 WP_174469047.1 NZ_CP048429:3367001-3367252 [Paenibacillus jilunlii]
MISLPDHLLQEVDGIVQLENSNRSELIRQAMKLYLSERRKRTIRDSMQRGYMEMAKINLTMACEAFLAEEDADSTLGRLV
SGV

Download         Length: 252 bp

>AT149418 NZ_CP064095:3901082-3901261 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E4H7G2

Antitoxin

Source ID Structure

References