Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4641100..4641716 | Replicon | chromosome |
Accession | NZ_CP048416 | ||
Organism | Citrobacter freundii strain CitB |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0J1MQ96 |
Locus tag | GZ999_RS21835 | Protein ID | WP_003028682.1 |
Coordinates | 4641100..4641474 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A6B5NTK4 |
Locus tag | GZ999_RS21840 | Protein ID | WP_043018956.1 |
Coordinates | 4641474..4641716 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GZ999_RS21820 | 4638603..4639505 | + | 903 | WP_003847898.1 | formate dehydrogenase O subunit beta | - |
GZ999_RS21825 | 4639502..4640137 | + | 636 | WP_003028686.1 | formate dehydrogenase cytochrome b556 subunit | - |
GZ999_RS21830 | 4640134..4641063 | + | 930 | WP_003028685.1 | formate dehydrogenase accessory protein FdhE | - |
GZ999_RS21835 | 4641100..4641474 | - | 375 | WP_003028682.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
GZ999_RS21840 | 4641474..4641716 | - | 243 | WP_043018956.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
GZ999_RS21845 | 4641922..4642830 | + | 909 | WP_003847901.1 | alpha/beta hydrolase | - |
GZ999_RS21850 | 4642981..4643922 | - | 942 | WP_003825286.1 | fatty acid biosynthesis protein FabY | - |
GZ999_RS21855 | 4643967..4644404 | - | 438 | WP_003028671.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
GZ999_RS21860 | 4644401..4645273 | - | 873 | WP_003028669.1 | virulence factor BrkB family protein | - |
GZ999_RS21865 | 4645267..4645866 | - | 600 | WP_003028663.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13674.89 Da Isoelectric Point: 9.5622
>T149412 WP_003028682.1 NZ_CP048416:c4641474-4641100 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL
Download Length: 375 bp
>T149412 NZ_CP064094:3466149-3466325 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9451.75 Da Isoelectric Point: 4.3437
>AT149412 WP_043018956.1 NZ_CP048416:c4641716-4641474 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW
Download Length: 243 bp
>AT149412 NZ_CP064094:c3466366-3466266 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1MQ96 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B5NTK4 |