149411

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4489578..4490244 Replicon chromosome
Accession NZ_CP048416
Organism Citrobacter freundii strain CitB

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag GZ999_RS21155 Protein ID WP_048216973.1
Coordinates 4489885..4490244 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0J1QJH0
Locus tag GZ999_RS21150 Protein ID WP_032938223.1
Coordinates 4489578..4489895 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ999_RS21115 4484757..4485554 + 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
GZ999_RS21120 4485566..4486390 + 825 WP_048216971.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
GZ999_RS21125 4486458..4487681 + 1224 WP_003031639.1 L-sorbose 1-phosphate reductase -
GZ999_RS21130 4487683..4488495 + 813 WP_048216972.1 shikimate 5-dehydrogenase -
GZ999_RS21135 4488545..4488901 - 357 WP_032938220.1 hypothetical protein -
GZ999_RS21140 4489033..4489206 + 174 WP_032938222.1 hypothetical protein -
GZ999_RS21145 4489277..4489438 + 162 WP_003841416.1 phage protein -
GZ999_RS21150 4489578..4489895 - 318 WP_032938223.1 helix-turn-helix domain-containing protein Antitoxin
GZ999_RS21155 4489885..4490244 - 360 WP_048216973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZ999_RS21160 4490458..4491147 + 690 WP_003841421.1 dipeptidase PepE -
GZ999_RS21165 4491213..4492844 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13410.46 Da        Isoelectric Point: 10.2555

>T149411 WP_048216973.1 NZ_CP048416:c4490244-4489885 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T149411 NZ_CP064094:3466149-3466325 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11451.29 Da        Isoelectric Point: 6.9796

>AT149411 WP_032938223.1 NZ_CP048416:c4489895-4489578 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp

>AT149411 NZ_CP064094:c3466208-3466108 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1QJH0

References