Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4235760..4236276 Replicon chromosome
Accession NZ_CP048416
Organism Citrobacter freundii strain CitB

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GZ999_RS19945 Protein ID WP_048216920.1
Coordinates 4235760..4236044 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag GZ999_RS19950 Protein ID WP_003839576.1
Coordinates 4236034..4236276 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZ999_RS19930 4232085..4232669 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
GZ999_RS19935 4233047..4235185 + 2139 WP_003839582.1 anaerobic ribonucleoside-triphosphate reductase -
GZ999_RS19940 4235292..4235756 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GZ999_RS19945 4235760..4236044 - 285 WP_048216920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZ999_RS19950 4236034..4236276 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GZ999_RS19955 4236354..4238267 - 1914 WP_048241736.1 BglG family transcription antiterminator -
GZ999_RS19960 4238289..4239029 - 741 WP_129622263.1 KDGP aldolase family protein -
GZ999_RS19965 4239026..4240144 - 1119 WP_048216923.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
GZ999_RS19970 4240128..4241261 - 1134 WP_048216924.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10905.80 Da        Isoelectric Point: 10.1715

>T149410 WP_048216920.1 NZ_CP048416:c4236044-4235760 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDKVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T149410 NZ_CP064094:c3412515-3412399 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT149410 WP_003839576.1 NZ_CP048416:c4236276-4236034 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT149410 NZ_CP064094:3412225-3412404 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References